Stephen Liberles

Stephen Liberles, Ph.D.

Professor of Cell Biology, Harvard Medical School
Tutor in Molecular and Cellular Biology, Faculty of Arts & Sciences

Stephen Liberles, Ph.D. is a Professor and HHMI Investigator in the Cell Biology Department at Harvard Medical School. Dr. Liberles received an undergraduate degree in Chemistry from Harvard in 1994, and a Ph.D. in Chemistry and Chemical Biology from Harvard in 1999, working in the lab of Stuart Schreiber. He then performed post-doctoral work in the lab of Linda Buck, first at Harvard Medical School and then at the Fred Hutchinson Cancer Research Center in Seattle.

The Liberles Lab focuses on the molecular neuroscience of sensory systems, including olfaction, pheromone sensing, taste, and internal organ senses of the vagus nerve. Some discoveries from his lab include characterizing non-classical families of olfactory receptors, odors and pheromones that stimulate innate behaviors, vagus nerve cell types that selectively control autonomic physiology, and mechanisms underlying sensation within internal organs, including airway stretch and changes in aortic blood pressure.

Harvard Medical School

Dept. of Cell Biology, LHRRB 601A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7283

Lab fax: 617-432-7285

Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity.
Authors: Authors: Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD.
ACS Chem Biol
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Detection and avoidance of a carnivore odor by prey.
Authors: Authors: Ferrero DM, Lemon JK, Fluegge D, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD.
Proc Natl Acad Sci U S A
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The secret codes of mammalian scents.
Authors: Authors: Ferrero DM, Liberles SD.
Wiley Interdiscip Rev Syst Biol Med
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Trace amine-associated receptors are olfactory receptors in vertebrates.
Authors: Authors: Liberles SD.
Ann N Y Acad Sci
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Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ.
Authors: Authors: Liberles SD, Horowitz LF, Kuang D, Contos JJ, Wilson KL, Siltberg-Liberles J, Liberles DA, Buck LB.
Proc Natl Acad Sci U S A
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A second class of chemosensory receptors in the olfactory epithelium.
Authors: Authors: Liberles SD, Buck LB.
Nature
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A candidate taste receptor gene near a sweet taste locus.
Authors: Authors: Montmayeur JP, Liberles SD, Matsunami H, Buck LB.
Nat Neurosci
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Apoptosis-inducing natural products found in utero during murine pregnancy.
Authors: Authors: Liberles SD, Schreiber SL.
Chem Biol
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Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale.
Authors: Authors: Borchardt A, Liberles SD, Biggar SR, Crabtree GR, Schreiber SL.
Chem Biol
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Inducible gene expression and protein translocation using nontoxic ligands identified by a mammalian three-hybrid screen.
Authors: Authors: Liberles SD, Diver ST, Austin DJ, Schreiber SL.
Proc Natl Acad Sci U S A
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