Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling.
Authors: Authors: Fostier M, Evans DA, Artavanis-Tsakonas S, Baron M.
Genetics
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A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development.
Authors: Authors: Go MJ, Artavanis-Tsakonas S.
Genetics
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The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.
Authors: Authors: Varnum-Finney B, Purton LE, Yu M, Brashem-Stein C, Flowers D, Staats S, Moore KA, Le Roux I, Mann R, Gray G, Artavanis-Tsakonas S, Bernstein ID.
Blood
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Cell proliferation control by Notch signaling in Drosophila development.
Authors: Authors: Go MJ, Eastman DS, Artavanis-Tsakonas S.
Development
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Human deltex is a conserved regulator of Notch signalling.
Authors: Authors: Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S.
Nat Genet
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Notch inhibition of E47 supports the existence of a novel signaling pathway.
Authors: Authors: Ordentlich P, Lin A, Shen CP, Blaumueller C, Matsuno K, Artavanis-Tsakonas S, Kadesch T.
Mol Cell Biol
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The NOTCH receptor and its ligands.
Authors: Authors: Fleming RJ, Purcell K, Artavanis-Tsakonas S.
Trends Cell Biol
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Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.
Authors: Authors: Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM.
Mol Cell Biol
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Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements.
Authors: Authors: Matsuno K, Go MJ, Sun X, Eastman DS, Artavanis-Tsakonas S.
Development
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Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.
Authors: Authors: Sun X, Artavanis-Tsakonas S.
Development
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