Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Lab fax: 617-432-7050

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Authors: Authors: Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD.
Nat Genet
View full abstract on Pubmed
Calcium depletion dissociates and activates heterodimeric notch receptors.
Authors: Authors: Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC.
Mol Cell Biol
View full abstract on Pubmed
Notch signaling and the determination of appendage identity.
Authors: Authors: Kurata S, Go MJ, Artavanis-Tsakonas S, Gehring WJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Contact-dependent inhibition of cortical neurite growth mediated by notch signaling.
Authors: Authors: Sestan N, Artavanis-Tsakonas S, Rakic P.
Science
View full abstract on Pubmed
Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling.
Authors: Authors: Hing HK, Bangalore L, Sun X, Artavanis-Tsakonas S.
Eur J Cell Biol
View full abstract on Pubmed
The developmental role of warthog, the notch modifier encoding Drab6.
Authors: Authors: Purcell K, Artavanis-Tsakonas S.
J Cell Biol
View full abstract on Pubmed
The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.
Authors: Authors: Cornell M, Evans DA, Mann R, Fostier M, Flasza M, Monthatong M, Artavanis-Tsakonas S, Baron M.
Genetics
View full abstract on Pubmed
Notch signaling: cell fate control and signal integration in development.
Authors: Authors: Artavanis-Tsakonas S, Rand MD, Lake RJ.
Science
View full abstract on Pubmed
Human ligands of the Notch receptor.
Authors: Authors: Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S.
Am J Pathol
View full abstract on Pubmed
Processing of the notch ligand delta by the metalloprotease Kuzbanian.
Authors: Authors: Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S.
Science
View full abstract on Pubmed