Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Lab fax: 617-432-7050

Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.
Authors: Authors: Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A, Artavanis-Tsakonas S.
Am J Pathol
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The Drosophila F box protein archipelago regulates dMyc protein levels in vivo.
Authors: Authors: Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK.
Curr Biol
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Accessing the Exelixis collection.
Authors: Authors: Artavanis-Tsakonas S.
Nat Genet
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Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process.
Authors: Authors: Grandbarbe L, Bouissac J, Rand M, Hrabé de Angelis M, Artavanis-Tsakonas S, Mohier E.
Development
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Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster.
Authors: Authors: Beltran S, Blanco E, Serras F, Pérez-Villamil B, Guigó R, Artavanis-Tsakonas S, Corominas M.
Proc Natl Acad Sci U S A
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Delta-Notch signaling controls the generation of
neurons/glia from neural stem cells in a stepwise process
Authors: Authors: Grandbarbe, L., Bouissac, J., Rand, M., Hrabe de Angelis, M., Artavanis-Tsakonas, S., and Mohier, E.,
Development

Down-regulation of Delta by proteolytic processing.
Authors: Authors: Mishra-Gorur K, Rand MD, Perez-Villamil B, Artavanis-Tsakonas S.
J Cell Biol
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Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling.
Authors: Authors: Matsuno K, Ito M, Hori K, Miyashita F, Suzuki S, Kishi N, Artavanis-Tsakonas S, Okano H.
Development
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Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.
Authors: Authors: Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S, Varga JL.
Proc Natl Acad Sci U S A
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Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.
Authors: Authors: Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K.
Int J Dev Neurosci
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