Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Lab fax: 617-432-7050

Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless.
Authors: Authors: Kelly DF, Lake RJ, Walz T, Artavanis-Tsakonas S.
Proc Natl Acad Sci U S A
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Crossing paths with Notch in the hyper-network.
Authors: Authors: Hurlbut GD, Kankel MW, Lake RJ, Artavanis-Tsakonas S.
Curr Opin Cell Biol
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Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice.
Authors: Authors: Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A.
Proc Natl Acad Sci U S A
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Notch signalling in vertebrate neural development.
Authors: Authors: Louvi A, Artavanis-Tsakonas S.
Nat Rev Neurosci
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Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.
Authors: Authors: Mourikis P, Hurlbut GD, Artavanis-Tsakonas S.
Proc Natl Acad Sci U S A
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CADASIL: a critical look at a Notch disease.
Authors: Authors: Louvi A, Arboleda-Velasquez JF, Artavanis-Tsakonas S.
Dev Neurosci
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Regulation of Notch signalling by non-visual beta-arrestin.
Authors: Authors: Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis-Tsakonas S.
Nat Cell Biol
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Notch signals control the fate of immature progenitor cells in the intestine.
Authors: Authors: Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, Artavanis-Tsakonas S.
Nature
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Analyzing protein complexes in Drosophila with tandem affinity purification-mass spectrometry.
Authors: Authors: Veraksa A, Bauer A, Artavanis-Tsakonas S.
Dev Dyn
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[Notch signals control the fate of immature progenitor cells in the intestine].
Authors: Authors: Robine S, Fre S, Huyghe M, Artavanis-Tsakonas S, Louvard D.
Med Sci (Paris)
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