Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Lab fax: 617-432-7050

Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target.
Authors: Authors: Kankel MW, Sen A, Lu L, Theodorou M, Dimlich DN, McCampbell A, Henderson CE, Shneider NA, Artavanis-Tsakonas S.
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The Notch pathway in CNS homeostasis and neurodegeneration.
Authors: Authors: Ho DM, Artavanis-Tsakonas S, Louvi A.
Wiley Interdiscip Rev Dev Biol
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PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis.
Authors: Authors: Sarraf SA, Sideris DP, Giagtzoglou N, Ni L, Kankel MW, Sen A, Bochicchio LE, Huang CH, Nussenzweig SC, Worley SH, Morton PD, Artavanis-Tsakonas S, Youle RJ, Pickrell AM.
Cell Rep
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Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone.
Authors: Authors: Engler A, Rolando C, Giachino C, Saotome I, Erni A, Brien C, Zhang R, Zimber-Strobl U, Radtke F, Artavanis-Tsakonas S, Louvi A, Taylor V.
Cell Rep
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The Notch Interactome: Complexity in Signaling Circuitry.
Authors: Authors: Ho DM, Guruharsha KG, Artavanis-Tsakonas S.
Adv Exp Med Biol
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Architecture of the human interactome defines protein communities and disease networks.
Authors: Authors: Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW.
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The Notch-Mediated Proliferation Circuitry.
Authors: Authors: Ho DM, Artavanis-Tsakonas S.
Curr Top Dev Biol
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Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila.
Authors: Authors: Stoiber MH, Olson S, May GE, Duff MO, Manent J, Obar R, Guruharsha KG, Bickel PJ, Artavanis-Tsakonas S, Brown JB, Graveley BR, Celniker SE.
Genome Res
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The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis.
Authors: Authors: Ho DM, Pallavi SK, Artavanis-Tsakonas S.
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The BioPlex Network: A Systematic Exploration of the Human Interactome.
Authors: Authors: Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, Tam S, Zarraga G, Colby G, Baltier K, Dong R, Guarani V, Vaites LP, Ordureau A, Rad R, Erickson BK, Wühr M, Chick J, Zhai B, Kolippakkam D, Mintseris J, Obar RA, Harris T, Artavanis-Tsakonas S, Sowa ME, De Camilli P, Paulo JA, Harper JW, Gygi SP.
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