Spyros Artavanis-Tsakonas

Spyros Artavanis-Tsakonas, Ph.D.

Professor of Cell Biology, Emeritus (HMS)
Professeur au Collège de France

Spyros Artavanis-Tsakonas, Ph.D., is Professor Emeritus of Cell Biology but continues to maintain a research group. He received his doctoral degree at Cambridge University, England and pursued postdoctoral research at the University of Basel, Switzerland, and Stanford University. He has been a faculty member at Harvard Medical School's Cell Biology department since 1998, and was Chief Scientific Officer at Biogen from 2012 until 2016.

Using molecular and genetic approaches, the Artavanis-Tsakonas lab is examining how various signals are integrated in undifferentiated cells in order to dictate cell fates. Our main experimental system is Drosophila and are interested in exploiting this system as a tool to explore human biology and understand the underlying mechanisms of pathologies with the current focus on neurodegeneration.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301C

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-7107

Lab fax: 617-432-7050

Transcription factor networks in Drosophila melanogaster.
Authors: Authors: Rhee DY, Cho DY, Zhai B, Slattery M, Ma L, Mintseris J, Wong CY, White KP, Celniker SE, Przytycka TM, Gygi SP, Obar RA, Artavanis-Tsakonas S.
Cell Rep
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Genetic circuitry modulating notch signals through endosomal trafficking.
Authors: Authors: Hori K, Sen A, Artavanis-Tsakonas S.
Methods Enzymol
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Proteomic analysis of the Notch interactome.
Authors: Authors: Guruharsha KG, Hori K, Obar RA, Artavanis-Tsakonas S.
Methods Mol Biol
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In vivo mapping of notch pathway activity in normal and stress hematopoiesis.
Authors: Authors: Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manet J, van Handel B, Ibrahim S, Greve J, Mikkola H, Artavanis-Tsakonas S, Aifantis I.
Cell Stem Cell
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Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.
Authors: Authors: Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S.
Proc Natl Acad Sci U S A
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Notch signaling at a glance.
Authors: Authors: Hori K, Sen A, Artavanis-Tsakonas S.
J Cell Sci
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An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling.
Authors: Authors: Fleming RJ, Hori K, Sen A, Filloramo GV, Langer JM, Obar RA, Artavanis-Tsakonas S, Maharaj-Best AC.
Development
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Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages.
Authors: Authors: Šale S, Lafkas D, Artavanis-Tsakonas S.
Nat Cell Biol
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The Notch signalling system: recent insights into the complexity of a conserved pathway.
Authors: Authors: Guruharsha KG, Kankel MW, Artavanis-Tsakonas S.
Nat Rev Genet
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Regulation of ligand-independent Notch signal through intracellular trafficking.
Authors: Authors: Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S.
Commun Integr Biol
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