Randall King

Randall King, M.D., Ph.D.

Harry C. McKenzie Professor of Cell Biology (HMS)
C-666
617-432-3629
King Lab

Randy King, M.D., Ph.D. was appointed to the faculty in 2000, after three years as the first Institute Fellow of the Institute of Chemistry of Cell Biology at Harvard. He received his undergraduate degree from Carleton College, followed by a Ph.D. in Biochemistry from UCSF, where he co-discovered the Anaphase-Promoting complex/Cyclosome (APC), and M.D. from Harvard Medical School. He was named the Harry C. McKenzie Professor of Cell Biology in 2013 and has received numerous awards in recognition of his contributions to medical education.

The King lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.

Harvard Medical School

Dept. of Cell Biology, C-666

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-4964

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
Authors: Authors: Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ.
Science
View full abstract on Pubmed
Identification of a cullin homology region in a subunit of the anaphase-promoting complex.
Authors: Authors: Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW.
Science
View full abstract on Pubmed
Cell cycle control by ubiquitin-dependent proteolysis
Authors: Authors: Peters JM, King RW, Deshaies RJ
Ubiquitin and the Biology of the Cell, Peters JM, Harris JR, and Finley D, Eds
Expression cloning in the test tube.
Authors: Authors: King RW, Lustig KD, Stukenberg PT, McGarry TJ, Kirschner MW.
Science
View full abstract on Pubmed
Systematic identification of mitotic phosphoproteins.
Authors: Authors: Stukenberg PT, Lustig KD, McGarry TJ, King RW, Kuang J, Kirschner MW.
Curr Biol
View full abstract on Pubmed
How proteolysis drives the cell cycle.
Authors: Authors: King RW, Deshaies RJ, Peters JM, Kirschner MW.
Science
View full abstract on Pubmed
Identification of BIME as a subunit of the anaphase-promoting complex.
Authors: Authors: Peters JM, King RW, Höög C, Kirschner MW.
Science
View full abstract on Pubmed
Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.
Authors: Authors: King RW, Glotzer M, Kirschner MW.
Mol Biol Cell
View full abstract on Pubmed
Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation.
Authors: Authors: Yu H, King RW, Peters JM, Kirschner MW.
Curr Biol
View full abstract on Pubmed
A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B.
Authors: Authors: King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW.
Cell
View full abstract on Pubmed