Randall King

Randall King, M.D., Ph.D.

Harry C. McKenzie Professor of Cell Biology (HMS)
C-666
617-432-3629
King Lab

Randy King, M.D., Ph.D. was appointed to the faculty in 2000, after three years as the first Institute Fellow of the Institute of Chemistry of Cell Biology at Harvard. He received his undergraduate degree from Carleton College, followed by a Ph.D. in Biochemistry from UCSF, where he co-discovered the Anaphase-Promoting complex/Cyclosome (APC), and M.D. from Harvard Medical School. He was named the Harry C. McKenzie Professor of Cell Biology in 2013 and has received numerous awards in recognition of his contributions to medical education.

The King lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.

Harvard Medical School

Dept. of Cell Biology, C-666

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-4964

Lab fax: 617-432-3702

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.
Authors: Authors: Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ.
Nat Cell Biol
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A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens.
Authors: Authors: Sigoillot FD, Lyman S, Huckins JF, Adamson B, Chung E, Quattrochi B, King RW.
Nat Methods
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APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.
Authors: Authors: Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D, King RW.
Nat Cell Biol
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High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
Authors: Authors: Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS.
Chem Biol
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Stuck in the middle: drugging the ubiquitin system at the e2 step.
Authors: Authors: Harper JW, King RW.
Cell
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Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.
Authors: Authors: Lee MJ, Lee BH, Hanna J, King RW, Finley D.
Mol Cell Proteomics
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A non-genetic route to aneuploidy in human cancers.
Authors: Authors: Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M.
Nat Cell Biol
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Vigilance and validation: Keys to success in RNAi screening.
Authors: Authors: Sigoillot FD, King RW.
ACS Chem Biol
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A time-series method for automated measurement of changes in mitotic and interphase duration from time-lapse movies.
Authors: Authors: Sigoillot FD, Huckins JF, Li F, Zhou X, Wong ST, King RW.
PLoS One
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Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.
Authors: Authors: Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW.
Cancer Cell
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