Randall King

Randall King, M.D., Ph.D.

Harry C. McKenzie Professor of Cell Biology (HMS)
C-666
617-432-3629
King Lab

Randy King, M.D., Ph.D. was appointed to the faculty in 2000, after three years as the first Institute Fellow of the Institute of Chemistry of Cell Biology at Harvard. He received his undergraduate degree from Carleton College, followed by a Ph.D. in Biochemistry from UCSF, where he co-discovered the Anaphase-Promoting complex/Cyclosome (APC), and M.D. from Harvard Medical School. He was named the Harry C. McKenzie Professor of Cell Biology in 2013 and has received numerous awards in recognition of his contributions to medical education.

The King lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.

Harvard Medical School

Dept. of Cell Biology, C-666

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-4964

Lab fax: 617-432-3702

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites.
Authors: Authors: Lee BH, Lu Y, Prado MA, Shi Y, Tian G, Sun S, Elsasser S, Gygi SP, King RW, Finley D.
Nature
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Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells.
Authors: Authors: Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, Fostier K, Kassambara A, Moreaux J, Hose D, Leleu X, King RW, Vanderkerken K, Van Valckenborgh E.
Oncotarget
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Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
Authors: Authors: de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RMF.
Nat Commun
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Substrate degradation by the proteasome: a single-molecule kinetic analysis.
Authors: Authors: Lu Y, Lee BH, King RW, Finley D, Kirschner MW.
Science
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Sculpting the proteome with small molecules.
Authors: Authors: King RW, Finley D.
Nat Chem Biol
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Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Authors: Authors: Sackton KL, Dimova N, Zeng X, Tian W, Zhang M, Sackton TB, Meaders J, Pfaff KL, Sigoillot F, Yu H, Luo X, King RW.
Nature
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The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.
Authors: Authors: Lim HJ, Dimova NV, Tan MK, Sigoillot FD, King RW, Shi Y.
Mol Cell Biol
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Determinants of human cyclin B1 association with mitotic chromosomes.
Authors: Authors: Pfaff KL, King RW.
PLoS One
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A High-Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14.
Authors: Authors: Lee BH, Finley D, King RW.
Curr Protoc Chem Biol
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An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination.
Authors: Authors: Zeng X, King RW.
Nat Chem Biol
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