Randall King

Randall King, M.D., Ph.D.

Harry C. McKenzie Professor of Cell Biology (HMS)
C-666
617-432-3629
King Lab

Randy King, M.D., Ph.D. was appointed to the faculty in 2000, after three years as the first Institute Fellow of the Institute of Chemistry of Cell Biology at Harvard. He received his undergraduate degree from Carleton College, followed by a Ph.D. in Biochemistry from UCSF, where he co-discovered the Anaphase-Promoting complex/Cyclosome (APC), and M.D. from Harvard Medical School. He was named the Harry C. McKenzie Professor of Cell Biology in 2013 and has received numerous awards in recognition of his contributions to medical education.

The King lab integrates chemical and cell biological approaches to study cell division and chromosome segregation.

Harvard Medical School

Dept. of Cell Biology, C-666

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-4964

Lab fax: 617-432-3702

Substrate identification and specificity profiling of deubiquitylases against endogenously-generated ubiquitin-protein conjugates.
Authors: Authors: Rossio V, Paulo JA, Liu X, Gygi SP, King RW.
bioRxiv
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Using cognitive load theory to evaluate and improve preparatory materials and study time for the flipped classroom.
Authors: Authors: Fischer K, Sullivan AM, Cohen AP, King RW, Cockrill BA, Besche HC.
BMC Med Educ
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Identification of Deubiquitinase Substrates in Xenopus Egg Extract.
Authors: Authors: Rossio V, Paulo JA, King RW.
Methods Mol Biol
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Advanced Integrated Science Courses: Building a Skill Set to Engage With the Interface of Research and Medicine.
Authors: Authors: Miloslavsky EM, Besche HC, Calderwood SB, Chang BS, Dienstag JL, King RW, Mitchell RN, Schwartzstein RM, Thomas H, Hundert EM, Flanagan JG.
Acad Med
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Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity.
Authors: Authors: Rossio V, Paulo JA, Chick J, Brasher B, Gygi SP, King RW.
Cell Chem Biol
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The Harvard Medical School Pathways Curriculum: Reimagining Developmentally Appropriate Medical Education for Contemporary Learners.
Authors: Authors: Schwartzstein RM, Dienstag JL, King RW, Chang BS, Flanagan JG, Besche HC, Hoenig MP, Miloslavsky EM, Atkins KM, Puig A, Cockrill BA, Wittels KA, Dalrymple JL, Gooding H, Hirsh DA, Alexander EK, Fazio SB, Hundert EM.
Acad Med
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The Insulin Receptor Adaptor IRS2 is an APC/C Substrate That Promotes Cell Cycle Protein Expression and a Robust Spindle Assembly Checkpoint.
Authors: Authors: Manohar S, Yu Q, Gygi SP, King RW.
Mol Cell Proteomics
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The Insulin Receptor Adaptor IRS2 is an APC/C Substrate That Promotes Cell Cycle Protein Expression and a Robust Spindle Assembly Checkpoint.
Authors: Authors: Manohar S, Yu Q, Gygi SP, King RW.
Mol Cell Proteomics
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Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20.
Authors: Authors: Richeson KV, Bodrug T, Sackton KL, Yamaguchi M, Paulo JA, Gygi SP, Schulman BA, Brown NG, King RW.
Nat Chem Biol
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An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
Authors: Authors: Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D.
J Biol Chem
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