Headshot of Rachel Wolfson

Rachel Wolfson, M.D., Ph.D.

Assistant Professor of Cell Biology (HMS)

Rachel Wolfson, M.D. Ph.D. joined the Harvard Medical School faculty as an Assistant Professor of Cell Biology in September 2024. She received her M.D. from Harvard Medical School and Ph.D. from Massachusetts Institute of Technology. She subsequently performed clinical training at Massachusetts General Hospital and postdoctoral research in the Department of Neurobiology at Harvard Medical School.

The Wolfson Lab studies mechanisms of internal sensation. Visceral innervating sensory neurons have cell bodies that reside in the dorsal root ganglia (DRG). The DRG sensory neurons target internal organs, such as the gastrointestinal tract, and sense internal stimuli. The Wolfson Lab uses neurobiology, biochemistry, and molecular biology techniques to understand the mechanisms through which visceral innervating sensory neurons sense a diversity of stimuli and then control physiologic and pathophysiologic processes.

Harvard Medical School

Dept. of Cell Biology - SGM 502B

240 Longwood Avenue

Boston, MA 02115

Lab Phone:

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.
Authors: Authors: Wolfson RL, Abdelaziz A, Rankin G, Kushner S, Qi L, Mazor O, Choi S, Sharma N, Ginty DD.
Cell
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Parallel ascending spinal pathways for affective touch and pain.
Authors: Authors: Choi S, Hachisuka J, Brett MA, Magee AR, Omori Y, Iqbal NU, Zhang D, DeLisle MM, Wolfson RL, Bai L, Santiago C, Gong S, Goulding M, Heintz N, Koerber HR, Ross SE, Ginty DD.
Nature
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Clinical Impact of Tumor Mutational Burden in Neuroblastoma.
Authors: Authors: Hwang WL, Wolfson RL, Niemierko A, Marcus KJ, DuBois SG, Haas-Kogan D.
J Natl Cancer Inst
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A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.
Authors: Authors: Yuskaitis CJ, Jones BM, Wolfson RL, Super CE, Dhamne SC, Rotenberg A, Sabatini DM, Sahin M, Poduri A.
Neurobiol Dis
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mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
Authors: Authors: Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM.
Cell
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The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.
Authors: Authors: Wolfson RL, Sabatini DM.
Cell Metab
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KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
Authors: Authors: Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM.
Nature
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Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
Authors: Authors: Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J.
Nat Genet
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Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
Authors: Authors: Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J.
Nat Genet
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Sestrin2 is a leucine sensor for the mTORC1 pathway.
Authors: Authors: Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM.
Science
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