Headshot of Rachel Wolfson

Rachel Wolfson, M.D., Ph.D.

Assistant Professor of Cell Biology (HMS)

Rachel Wolfson, M.D. Ph.D. joined the Harvard Medical School faculty as an Assistant Professor of Cell Biology in September 2024. She received her M.D. from Harvard Medical School and Ph.D. from Massachusetts Institute of Technology. She subsequently performed clinical training at Massachusetts General Hospital and postdoctoral research in the Department of Neurobiology at Harvard Medical School.

The Wolfson Lab studies mechanisms of internal sensation. Visceral innervating sensory neurons have cell bodies that reside in the dorsal root ganglia (DRG). The DRG sensory neurons target internal organs, such as the gastrointestinal tract, and sense internal stimuli. The Wolfson Lab uses neurobiology, biochemistry, and molecular biology techniques to understand the mechanisms through which visceral innervating sensory neurons sense a diversity of stimuli and then control physiologic and pathophysiologic processes.

Harvard Medical School

Dept. of Cell Biology - SGM 502B

240 Longwood Avenue

Boston, MA 02115

Lab Phone:

Sestrin2 is a leucine sensor for the mTORC1 pathway.
Authors: Authors: Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM.
Science
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Nutrient-sensing mechanisms across evolution.
Authors: Authors: Chantranupong L, Wolfson RL, Sabatini DM.
Cell
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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Authors: Authors: Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM.
Science
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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
Authors: Authors: Chantranupong L, Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L, Spooner E, Isasa M, Gygi SP, Sabatini DM.
Cell Rep
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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
Authors: Authors: Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM.
Nature
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