Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Mitochondrial Sirtuins and Molecular Mechanisms of Aging.
Authors: Authors: van de Ven RAH, Santos D, Haigis MC.
Trends Mol Med
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Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.
Authors: Authors: Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH.
Nat Immunol
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Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.
Authors: Authors: Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC.
Cell
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PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
Authors: Authors: German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG, Haigis MC.
Mol Cell
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Mitochondria and Cancer.
Authors: Authors: Vyas S, Zaganjor E, Haigis MC.
Cell
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Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.
Authors: Authors: Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC.
Cell Metab
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Nuclear respiratory factor 2 induces SIRT3 expression.
Authors: Authors: Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MC.
Aging Cell
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Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism.
Authors: Authors: Jeong SM, Haigis MC.
Mol Cells
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Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.
Authors: Authors: Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH.
Cell Rep
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Sirtuins and the Metabolic Hurdles in Cancer.
Authors: Authors: German NJ, Haigis MC.
Curr Biol
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