Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
Authors: Authors: Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC.
Oncogene
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Intersections between mitochondrial sirtuin signaling and tumor cell metabolism.
Authors: Authors: Gonzalez Herrera KN, Lee J, Haigis MC.
Crit Rev Biochem Mol Biol
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Mitochondrial metabolism in T cell activation and senescence: a mini-review.
Authors: Authors: Ron-Harel N, Sharpe AH, Haigis MC.
Gerontology
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Corrigendum: PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.
Authors: Authors: LeBleu VS, O'Connell JT, Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Chinen LT, Rocha RM, Asara JM, Kalluri R.
Nat Cell Biol
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PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.
Authors: Authors: LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R.
Nat Cell Biol
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Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.
Authors: Authors: Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K.
Proc Natl Acad Sci U S A
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Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
Authors: Authors: Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF.
Proc Natl Acad Sci U S A
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SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.
Authors: Authors: Jeong SM, Lee A, Lee J, Haigis MC.
J Biol Chem
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Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter.
Authors: Authors: Satterstrom FK, Haigis MC.
Methods Enzymol
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The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation.
Authors: Authors: Bause AS, Matsui MS, Haigis MC.
J Biol Chem
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