Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

SIRT1 shows no substrate specificity in vitro.
Authors: Authors: Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L.
J Biol Chem
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Ribonuclease inhibitor: structure and function.
Authors: Authors: Dickson KA, Haigis MC, Raines RT.
Prog Nucleic Acid Res Mol Biol
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Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria.
Authors: Authors: Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ.
Biochem J
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Calorie restriction extends yeast life span by lowering the level of NADH.
Authors: Authors: Lin SJ, Ford E, Haigis M, Liszt G, Guarente L.
Genes Dev
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Superoxide dismutase 1 knock-down induces senescence in human fibroblasts.
Authors: Authors: Blander G, de Oliveira RM, Conboy CM, Haigis M, Guarente L.
J Biol Chem
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Ribonuclease inhibitor as an intracellular sentry.
Authors: Authors: Haigis MC, Kurten EL, Raines RT.
Nucleic Acids Res
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Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway.
Authors: Authors: Haigis MC, Raines RT.
J Cell Sci
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Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein.
Authors: Authors: Abel RL, Haigis MC, Park C, Raines RT.
Anal Biochem
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Evolution of ribonuclease inhibitor by exon duplication.
Authors: Authors: Haigis MC, Haag ES, Raines RT.
Mol Biol Evol
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KFERQ sequence in ribonuclease A-mediated cytotoxicity.
Authors: Authors: Haigis MC, Kurten EL, Abel RL, Raines RT.
J Biol Chem
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