Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Lab fax: 617-432-6932

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Authors: Authors: Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter J, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A.
bioRxiv
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A metabolomic signature of the APOE2 allele.
Authors: Authors: Sebastiani P, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Lustgarten MS, Funk CC, Baloni P, Yao CH, Joshi S, Marron MM, Gurinovich A, Li M, Leshchyk A, Xiang Q, Andersen SL, Feitosa MF, Ukraintseva S, Soerensen M, Fiehn O, Ordovas JM, Haigis M, Monti S, Barzilai N, Milman S, Ferrucci L, Rappaport N, Patti GJ, Perls TT.
Geroscience
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Age-associated remodeling of T cell immunity and metabolism.
Authors: Authors: Han S, Georgiev P, Ringel AE, Sharpe AH, Haigis MC.
Cell Metab
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Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome.
Authors: Authors: Huang M, Akerberg AA, Zhang X, Yoon H, Joshi S, Hallinan C, Nguyen C, Pu WT, Haigis MC, Burns CG, Burns CE.
Nat Commun
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Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function.
Authors: Authors: Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC.
Science
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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells.
Authors: Authors: Elia I, Rowe JH, Johnson S, Joshi S, Notarangelo G, Kurmi K, Weiss S, Freeman GJ, Sharpe AH, Haigis MC.
Cell Metab
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Metabolomic and transcriptomic signatures of chemogenetic heart failure.
Authors: Authors: Spyropoulos F, Sorrentino A, van der Reest J, Yang P, Waldeck-Weiermair M, Steinhorn B, Eroglu E, Saeedi Saravi SS, Yu P, Haigis M, Christou H, Michel T.
Am J Physiol Heart Circ Physiol
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Dangerous dynamic duo: Lactic acid and PD-1 blockade.
Authors: Authors: Johnson S, Haigis MC, Dougan SK.
Cancer Cell
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Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers.
Authors: Authors: Stopka SA, van der Reest J, Abdelmoula WM, Ruiz DF, Joshi S, Ringel AE, Haigis MC, Agar NYR.
PLoS One
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Metabolic analyses reveal dysregulated NAD+ metabolism and altered mitochondrial state in ulcerative colitis.
Authors: Authors: Kang YH, Tucker SA, Quevedo SF, Inal A, Korzenik JR, Haigis MC.
PLoS One
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