Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)
LHRRB 301A
617-432-6865
Haigis Lab

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Lab fax: 617-432-6932

Faculty Assistant

Regulatory T cells in dominant immunologic tolerance.
Authors: Authors: Georgiev P, Benamar M, Han S, Haigis MC, Sharpe AH, Chatila TA.
J Allergy Clin Immunol
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Metabolic modulation of mitochondrial mass during CD4+ T cell activation.
Authors: Authors: Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MC.
Cell Chem Biol
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Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade.
Authors: Authors: Rowe JH, Elia I, Shahid O, Gaudiano EF, Sifnugel NE, Johnson S, Reynolds AG, Fung ME, Joshi S, LaFleur MW, Park JS, Pauken KE, Rabinowitz JD, Freeman GJ, Haigis MC, Sharpe AH.
Cancer Discov
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Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging.
Authors: Authors: Stopka SA, Ruiz D, Baquer G, Bodineau C, Hossain MA, Pellens VT, Regan MS, Pourquié O, Haigis MC, Bi WL, Coy SM, Santagata S, Agar NYR, Basu SS.
Anal Chem
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FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Authors: Authors: Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A.
Cell Metab
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Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.
Authors: Authors: Cable J, Rathmell JC, Pearce EL, Ho PC, Haigis MC, Mamedov MR, Wu MJ, Kaech SM, Lynch L, Febbraio MA, Bapat SP, Hong HS, Zou W, Belkaid Y, Sullivan ZA, Keller A, Wculek SK, Green DR, Postic C, Amit I, Benitah SA, Jones RG, Reina-Campos M, Torres SV, Beyaz S, Brennan D, O'Neill LAJ, Perry RJ, Brenner D.
Ann N Y Acad Sci
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Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis.
Authors: Authors: Yao CH, Park JS, Kurmi K, Hu SH, Notarangelo G, Crowley J, Jacobson H, Hui S, Sharpe AH, Haigis MC.
Mol Cell
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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Authors: Authors: Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L.
Cell Metab
View full abstract on Pubmed
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Authors: Authors: Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L.
Cell Metab
View full abstract on Pubmed
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Authors: Authors: Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter J, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A.
bioRxiv
View full abstract on Pubmed