Marcia Haigis
Marcia Haigis, Ph.D.
Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.


Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Lab fax: 617-432-6932

Development of a colorimetric a-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins.
Authors: Authors: Wong SJ, Ringel AE, Yuan W, Paulo JA, Yoon H, Currie MA, Haigis MC.
J Biol Chem
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Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells.
Authors: Authors: Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao CH, Kurmi K, Juneja VR, Trombley JD, Haigis MC, Sharpe AH.
Cancer Immunol Res
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Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism.
Authors: Authors: Elia I, Haigis MC.
Nat Metab
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
Authors: Authors: Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC.
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Astrocyte deletion of a2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.
Authors: Authors: Smith SE, Chen X, Brier LM, Bumstead JR, Rensing NR, Ringel AE, Shin H, Oldenborg A, Crowley JR, Bice AR, Dikranian K, Ippolito JE, Haigis MC, Papouin T, Zhao G, Wong M, Culver JP, Bonni A.
Nat Commun
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The effects of age and systemic metabolism on anti-tumor T cell responses.
Authors: Authors: Drijvers JM, Sharpe AH, Haigis MC.
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Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.
Authors: Authors: van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT.
Cell Metab
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PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle.
Authors: Authors: Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MC.
Cell Metab
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The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function.
Authors: Authors: Chen H, Shi Z, Guo J, Chang KJ, Chen Q, Yao CH, Haigis MC, Shi Y.
J Biol Chem
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REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors.
Authors: Authors: Qiao S, Koh SB, Vivekanandan V, Salunke D, Patra KC, Zaganjor E, Ross K, Mizukami Y, Jeanfavre S, Chen A, Mino-Kenudson M, Ramaswamy S, Clish C, Haigis M, Bardeesy N, Ellisen LW.
Genes Dev
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