Marcia Haigis

Marcia Haigis, Ph.D.

Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Lab fax: 617-432-6932

Widespread Neuroanatomical Integration and Distinct Electrophysiological Properties of Glioma-Innervating Neurons.
Authors: Authors: Hsieh AL, Ganesh S, Kula T, Irshad M, Ferenczi EA, Wang W, Chen YC, Hu SH, Li Z, Joshi S, Haigis MC, Sabatini BL.
bioRxiv
View full abstract on Pubmed
Age-associated contraction of tumor-specific T cells impairs antitumor immunity.
Authors: Authors: Georgiev P, Han S, Huang AY, Nguyen TH, Drijvers JM, Creasey H, Pereira JA, Yao CH, Park JS, Conway TS, Fung ME, Liang D, Peluso M, Joshi S, Rowe JH, Miller BC, Freeman GJ, Sharpe AH, Haigis MC, Ringel AE.
Cancer Immunol Res
View full abstract on Pubmed
pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism.
Authors: Authors: Landau LM, Chaudhary N, Tien YC, Rogozinska M, Joshi S, Yao C, Crowley J, Hullahalli K, Campbell IW, Waldor MK, Haigis M, Kagan JC.
Mol Cell
View full abstract on Pubmed
Profiling Proteins and Phosphorylation Sites During T Cell Activation Using an Integrated Thermal Shift Assay.
Authors: Authors: Gassaway BM, Huttlin EL, Huntsman EM, Yaron-Barir TM, Johnson JL, Kurmi K, Cantley LC, Paulo JA, Ringel AE, Gygi SP, Haigis MC.
Mol Cell Proteomics
View full abstract on Pubmed
Branched chain a-ketoacids aerobically activate HIF1a signaling in vascular cells.
Authors: Authors: Xiao W, Shrimali N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J.
bioRxiv
View full abstract on Pubmed
SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis.
Authors: Authors: Tucker SA, Hu SH, Vyas S, Park A, Joshi S, Inal A, Lam T, Tan E, Haigis KM, Haigis MC.
Cell Rep
View full abstract on Pubmed
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.
Authors: Authors: Pannek M, Alhalabi Z, Tomaselli D, Menna M, Fiorentino F, Robaa D, Weyand M, Puhlmann M, Tomassi S, Barreca F, Tafani M, Zaganjor E, Haigis MC, Sippl W, Rotili D, Mai A, Steegborn C.
J Med Chem
View full abstract on Pubmed
Regulatory T cells in dominant immunologic tolerance.
Authors: Authors: Georgiev P, Benamar M, Han S, Haigis MC, Sharpe AH, Chatila TA.
J Allergy Clin Immunol
View full abstract on Pubmed
Metabolic modulation of mitochondrial mass during CD4+ T cell activation.
Authors: Authors: Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MC.
Cell Chem Biol
View full abstract on Pubmed
Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade.
Authors: Authors: Rowe JH, Elia I, Shahid O, Gaudiano EF, Sifnugel NE, Johnson S, Reynolds AG, Fung ME, Joshi S, LaFleur MW, Park JS, Pauken KE, Rabinowitz JD, Freeman GJ, Haigis MC, Sharpe AH.
Cancer Discov
View full abstract on Pubmed