Marcia Haigis
Marcia Haigis, Ph.D.
Professor of Cell Biology (HMS)

Marcia C. Haigis, Ph.D. obtained her Ph.D. in Biochemistry from the University of Wisconsin in 2002 and performed postdoctoral studies at MIT studying mitochondrial metabolism. In 2006, Dr. Haigis joined the faculty of Harvard Medical School, where she is currently a Professor in the Department of Cell Biology. Dr. Haigis is an active member of the Paul F. Glenn Center for the Biology of Aging, a member of the Ludwig Center at Harvard Medical School, and was recently selected for the National Academy of Medicine Emerging Leaders in Health and Medicine Program.

The Haigis Lab aims to: 1) identify molecular mechanisms by which mitochondria respond to cellular stress and 2) elucidate how these cellular mechanisms contribute to aging and age-related diseases, such as cancer. The Haigis lab has made key contributions to our understanding of metabolic reprogramming in cancer, including identifying nodes of metabolic vulnerability in the control of fat oxidation in leukemia and metabolic recycling of ammonia to generate amino acids important for tumor growth.

Harvard Medical School

Dept. of Cell Biology, LHRRB 301A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6865

Lab fax: 617-432-6932

Metabolomic and transcriptomic signatures of chemogenetic heart failure.
Authors: Authors: Spyropoulos F, Sorrentino A, van der Reest J, Yang P, Waldeck-Weiermair M, Steinhorn B, Eroglu E, Saeedi Saravi SS, Yu P, Haigis M, Christou H, Michel T.
Am J Physiol Heart Circ Physiol
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Dangerous dynamic duo: Lactic acid and PD-1 blockade.
Authors: Authors: Johnson S, Haigis MC, Dougan SK.
Cancer Cell
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Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice.
Authors: Authors: van Gastel N, Spinelli JB, Haigis MC, Scadden DT.
Bio Protoc
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Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity.
Authors: Authors: Yoon H, Shaw JL, Haigis MC, Greka A.
Mol Cell
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Mitochondria: Their relevance during oocyte ageing.
Authors: Authors: van der Reest J, Nardini Cecchino G, Haigis MC, Kordowitzki P.
Ageing Res Rev
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Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.
Authors: Authors: Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef N.
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SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.
Authors: Authors: Zaganjor E, Yoon H, Spinelli JB, Nunn ER, Laurent G, Keskinidis P, Sivaloganathan S, Joshi S, Notarangelo G, Mulei S, Chvasta MT, Tucker SA, Kalafut K, van de Ven RAH, Clish CB, Haigis MC.
Cell Rep
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Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.
Authors: Authors: Zee BM, Poels KE, Yao CH, Kawabata KC, Wu G, Duy C, Jacobus WD, Senior E, Endress JE, Jambhekar A, Lovitch SB, Ma J, Dhall A, Harris IS, Blanco MA, Sykes DB, Licht JD, Weinstock DM, Melnick A, Haigis MC, Michor F, Shi Y.
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Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis.
Authors: Authors: Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI.
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The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.
Authors: Authors: Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J.
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