Malcolm Whitman

Malcolm Whitman, Ph.D.

Professor of Developmental Biology, Harvard School of Dental Medicine
Associate Dean for Basic Science Research (HSDM)

Malcolm Whitman, Ph.D., received his doctorate from Harvard University in 1985 while working on phosphatidylinositol kinases with Lew Cantley. After his postdoctoral studies with Doug Melton studying signaling in embryogenesis, also at Harvard, he joined the Cell Biology faculty at Harvard Medical School in 1992. In 2007, he became a Professor of Developmental Biology at the Harvard School of Dental Medicine.

The Whitman lab is interested in how signals are transduced into highly specific biological responses during embryogenesis, during physiological responses of an organism to stress or damage,  and  during the development of various disease pathologies.

Harvard School of Dental Medicine

Department of Developmental Biology, REB-505

188 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-432-1320

Lab fax: 617-432-3246

Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
Authors: Authors: Danciu TE, Chupreta S, Cruz O, Fox JE, Whitman M, Iñiguez-Lluhí JA.
J Biol Chem
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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Authors: Authors: Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M.
Nat Chem Biol
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Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells.
Authors: Authors: Kamberov YG, Kim J, Mazitschek R, Kuo WP, Whitman M.
BMC Res Notes
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Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors.
Authors: Authors: Danciu TE, Whitman M.
J Cell Biochem
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The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo.
Authors: Authors: Ho DM, Yeo CY, Whitman M.
Mech Dev
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Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.
Authors: Authors: Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A.
Science
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TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates.
Authors: Authors: Onuma Y, Watanabe A, Aburatani H, Asashima M, Whitman M.
Zoolog Sci
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Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.
Authors: Authors: Anderson SB, Goldberg AL, Whitman M.
J Biol Chem
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TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
Authors: Authors: Ho DM, Whitman M.
Dev Biol
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Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.
Authors: Authors: Ho DM, Chan J, Bayliss P, Whitman M.
Dev Biol
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