Malcolm Whitman

Malcolm Whitman, Ph.D.

Professor of Developmental Biology, Harvard School of Dental Medicine
Associate Dean for Basic Science Research (HSDM)
REB 505
617-432-1320
Whitman Lab

Malcolm Whitman, Ph.D., received his doctorate from Harvard University in 1985 while working on phosphatidylinositol kinases with Lew Cantley. After his postdoctoral studies with Doug Melton studying signaling in embryogenesis, also at Harvard, he joined the Cell Biology faculty at Harvard Medical School in 1992. In 2007, he became a Professor of Developmental Biology at the Harvard School of Dental Medicine.

The Whitman lab is interested in how signals are transduced into highly specific biological responses during embryogenesis, during physiological responses of an organism to stress or damage,  and  during the development of various disease pathologies.

Harvard School of Dental Medicine

Department of Developmental Biology, REB-505

188 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-432-1320

Lab fax: 617-432-3246

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
Authors: Authors: Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R.
Nat Commun
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Loss of Vlk in Prx1+ Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb.
Authors: Authors: Maridas DE, Gamer L, Moore ER, Doedens AM, Yu Y, Ionescu A, Revollo L, Whitman M, Rosen V.
J Bone Miner Res
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The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation.
Authors: Authors: Revollo L, Merrill-Skoloff G, De Ceunynck K, Dilks JR, Guo S, Bordoli MR, Peters CG, Noetzli L, Ionescu A, Rosen V, Italiano JE, Whitman M, Flaumenhaft R.
Blood
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Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Authors: Authors: Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL.
Proc Natl Acad Sci U S A
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Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
Authors: Authors: Oishi H, Martinu T, Sato M, Matsuda Y, Hirayama S, Juvet SC, Guan Z, Saito T, Cypel M, Hwang DM, Keller TL, Whitman MR, Liu M, Keshavjee S.
J Heart Lung Transplant
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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Authors: Authors: Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R.
Sci Transl Med
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Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.
Authors: Authors: Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB.
Arthritis Res Ther
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A secreted tyrosine kinase acts in the extracellular environment.
Authors: Authors: Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M.
Cell
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A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.
Authors: Authors: Rienhoff HY, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M.
Am J Med Genet A
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Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.
Authors: Authors: Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T.
Nat Med
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