Malcolm Whitman
Malcolm Whitman, Ph.D.
Professor of Developmental Biology, Harvard School of Dental Medicine
Associate Dean for Basic Science Research (HSDM)

Malcolm Whitman, Ph.D., received his doctorate from Harvard University in 1985 while working on phosphatidylinositol kinases with Lew Cantley. After his postdoctoral studies with Doug Melton studying signaling in embryogenesis, also at Harvard, he joined the Cell Biology faculty at Harvard Medical School in 1992. In 2007, he became a Professor of Developmental Biology at the Harvard School of Dental Medicine.

The Whitman lab is interested in how signals are transduced into highly specific biological responses during embryogenesis, during physiological responses of an organism to stress or damage,  and  during the development of various disease pathologies.

Harvard School of Dental Medicine

Department of Developmental Biology, REB-505

188 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-432-1320

Lab fax: 617-432-3246

Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Authors: Authors: Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL.
Proc Natl Acad Sci U S A
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Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
Authors: Authors: Oishi H, Martinu T, Sato M, Matsuda Y, Hirayama S, Juvet SC, Guan Z, Saito T, Cypel M, Hwang DM, Keller TL, Whitman MR, Liu M, Keshavjee S.
J Heart Lung Transplant
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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Authors: Authors: Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R.
Sci Transl Med
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Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.
Authors: Authors: Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB.
Arthritis Res Ther
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A secreted tyrosine kinase acts in the extracellular environment.
Authors: Authors: Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M.
Cell
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A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.
Authors: Authors: Rienhoff HY, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M.
Am J Med Genet A
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Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.
Authors: Authors: Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T.
Nat Med
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Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
Authors: Authors: Danciu TE, Chupreta S, Cruz O, Fox JE, Whitman M, Iñiguez-Lluhí JA.
J Biol Chem
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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Authors: Authors: Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M.
Nat Chem Biol
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Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells.
Authors: Authors: Kamberov YG, Kim J, Mazitschek R, Kuo WP, Whitman M.
BMC Res Notes
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