Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Authors: Authors: Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR.
Mol Cell Biol
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Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
Authors: Authors: Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H.
Proc Natl Acad Sci U S A
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Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis.
Authors: Authors: Holt LJ, Hutti JE, Cantley LC, Morgan DO.
Mol Cell
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Covalent reactions of wortmannin under physiological conditions.
Authors: Authors: Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L.
Chem Biol
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Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase.
Authors: Authors: Zheng B, Cantley LC.
Proc Natl Acad Sci U S A
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Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.
Authors: Authors: Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA.
Proc Natl Acad Sci U S A
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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.
Authors: Authors: Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, Tracy S, Zhao X, Heymach JV, Johnson BE, Cantley LC, Jänne PA.
J Clin Invest
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Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
Authors: Authors: Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR.
Proc Natl Acad Sci U S A
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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Authors: Authors: Engelman JA, Luo J, Cantley LC.
Nat Rev Genet
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The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors.
Authors: Authors: Engelman JA, Cantley LC.
Clin Cancer Res
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