Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Ras, PI(3)K and mTOR signalling controls tumour cell growth.
Authors: Authors: Shaw RJ, Cantley LC.
Nature
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Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.
Authors: Authors: Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC, Graf T, Shivdasani RA.
Blood
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Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.
Authors: Authors: Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR.
Cell Metab
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Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.
Authors: Authors: Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, Cantley LC.
Cell Metab
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MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen.
Authors: Authors: Turk BE, Lee DH, Yamakoshi Y, Klingenhoff A, Reichenberger E, Wright JT, Simmer JP, Komisarof JA, Cantley LC, Bartlett JD.
Biochemistry
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PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.
Authors: Authors: Pendaries C, Tronchère H, Arbibe L, Mounier J, Gozani O, Cantley L, Fry MJ, Gaits-Iacovoni F, Sansonetti PJ, Payrastre B.
EMBO J
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Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
Authors: Authors: Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW.
PLoS Biol
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Wortmannin-C20 conjugates generate wortmannin.
Authors: Authors: Yuan H, Luo J, Weissleder R, Cantley L, Josephson L.
J Med Chem
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In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification.
Authors: Authors: Asara JM, Zhang X, Zheng B, Christofk HH, Wu N, Cantley LC.
J Proteome Res
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Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates.
Authors: Authors: Turk BE, Hutti JE, Cantley LC.
Nat Protoc
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