Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.
Authors: Authors: Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW.
Mol Cell Biol
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Interpreting sequences from mastodon and T. rex.
Authors: Authors: Asara JM, Garavelli JS, Slatter DA, Schweitzer MH, Freimark LM, Phillips M, Cantley LC.
Science
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Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.
Authors: Authors: Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC.
Mol Cell Biol
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Biochemistry. PI3K charges ahead.
Authors: Authors: Lee JY, Engelman JA, Cantley LC.
Science
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AKT/PKB signaling: navigating downstream.
Authors: Authors: Manning BD, Cantley LC.
Cell
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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Authors: Authors: Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA.
Science
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Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis.
Authors: Authors: Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC.
Proc Natl Acad Sci U S A
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Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.
Authors: Authors: Asara JM, Schweitzer MH, Freimark LM, Phillips M, Cantley LC.
Science
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The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Authors: Authors: Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR.
Mol Cell Biol
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AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.
Authors: Authors: Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL.
Arch Dermatol
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