Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
Authors: Authors: Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP.
J Clin Invest
View full abstract on Pubmed
Slow self-activation enhances the potency of viridin prodrugs.
Authors: Authors: Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L.
J Med Chem
View full abstract on Pubmed
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
Authors: Authors: Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
Authors: Authors: Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.
J Clin Invest
View full abstract on Pubmed
A sweet new role for EGFR in cancer.
Authors: Authors: Engelman JA, Cantley LC.
Cancer Cell
View full abstract on Pubmed
Molecular phylogenetics of mastodon and Tyrannosaurus rex.
Authors: Authors: Organ CL, Schweitzer MH, Zheng W, Freimark LM, Cantley LC, Asara JM.
Science
View full abstract on Pubmed
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Authors: Authors: Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC.
Nature
View full abstract on Pubmed
Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Authors: Authors: Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC.
Nature
View full abstract on Pubmed
A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.
Authors: Authors: Asara JM, Christofk HR, Freimark LM, Cantley LC.
Proteomics
View full abstract on Pubmed
Fate of a bioactive fluorescent wortmannin derivative in cells.
Authors: Authors: Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L.
Bioconjug Chem
View full abstract on Pubmed