Headshot of Lewis Cantley

Lewis Cantley, Ph.D.

Professor of Cell Biology (HMS)
Dana-Farber Cancer Institute
TBA--

Lew Cantley is widely known for his many seminal discoveries in signaling and metabolism, including the identification of PI3 kinase and its role in transformation, as well as groundbreaking work unraveling the complexities of protein kinase signaling--his work has had major impact across virtually every aspect of cancer cell biology. For those of you who are new to the department, Lew was a Cell Bio faculty member from 1992-2003 before transitioning to the then newly formed HMS Department of Systems Biology in 2003. In 2012, Lew was recruited to Weill Cornell in New York City, where he served as Director of the Meyer Cancer Center. There, he built a remarkable program focused on the intersection of metabolism and signaling in cancer.

Lew rejoined the Department of Cell Biology at HMS and the DFCI-Cancer Cell Biology in 2022.  

Dana Farber Cancer Institute

Cancer Cell Biology

Faculty Assistant

AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.
Authors: Authors: Amato S, Liu X, Zheng B, Cantley L, Rakic P, Man HY.
Science
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Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.
Authors: Authors: Saci A, Cantley LC, Carpenter CL.
Mol Cell
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A fluorescent reporter of AMPK activity and cellular energy stress.
Authors: Authors: Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC.
Cell Metab
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Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations.
Authors: Authors: Yuan TL, Wulf G, Burga L, Cantley LC.
Curr Biol
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Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Authors: Authors: Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC.
Science
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Targeting a common collaborator in cancer development.
Authors: Authors: Myers AP, Cantley LC.
Sci Transl Med
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PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.
Authors: Authors: Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ, Arends MJ.
Proc Natl Acad Sci U S A
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The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
Authors: Authors: Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR.
Cancer Res
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Altered metabolism in cancer.
Authors: Authors: Locasale JW, Cantley LC.
BMC Biol
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Authors: Authors: Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM.
Nature
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