Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513B

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-3974

A structure-guided approach to creating covalent FGFR inhibitors.
Authors: Authors: Zhou W, Hur W, McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS.
Chem Biol
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Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Authors: Authors: Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS.
Proc Natl Acad Sci U S A
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MYC regulation of a "poor-prognosis" metastatic cancer cell state.
Authors: Authors: Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S.
Proc Natl Acad Sci U S A
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Mutant p53 drives invasion by promoting integrin recycling.
Authors: Authors: Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH.
Cell
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Tumor self-seeding: bidirectional flow of tumor cells.
Authors: Authors: Leung CT, Brugge JS.
Cell
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A stiff blow from the stroma: collagen crosslinking drives tumor progression.
Authors: Authors: Ng MR, Brugge JS.
Cancer Cell
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YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.
Authors: Authors: Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA.
Nat Cell Biol
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Activity of the multikinase inhibitor dasatinib against ovarian cancer cells.
Authors: Authors: Konecny GE, Glas R, Dering J, Manivong K, Qi J, Finn RS, Yang GR, Hong KL, Ginther C, Winterhoff B, Gao G, Brugge J, Slamon DJ.
Br J Cancer
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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.
Authors: Authors: Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS.
Nature
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YB-1 translational control of epithelial-mesenchyme transition.
Authors: Authors: Mouneimne G, Brugge JS.
Cancer Cell
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