Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

At the leading edge of cancer research: an interview with Joan Brugge. Interview by Sarah Allan.
Authors: Authors: Brugge J.
Dis Model Mech
View full abstract on Pubmed
Mechanistic biology in the next quarter century.
Authors: Authors: Harrison SC, Brugge JS.
Mol Biol Cell
View full abstract on Pubmed
Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.
Authors: Authors: Knowlton ML, Selfors LM, Wrobel CN, Gu TL, Ballif BA, Gygi SP, Polakiewicz R, Brugge JS.
PLoS One
View full abstract on Pubmed
PTK6 regulates IGF-1-induced anchorage-independent survival.
Authors: Authors: Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS.
PLoS One
View full abstract on Pubmed
Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis.
Authors: Authors: Tushir JS, Clancy J, Warren A, Wrobel C, Brugge JS, D'Souza-Schorey C.
Mol Biol Cell
View full abstract on Pubmed
Joan Brugge: running rings around cancer. Interview by Caitlin Sedwick.
Authors: Authors: Brugge J.
J Cell Biol
View full abstract on Pubmed
Identifying single-cell molecular programs by stochastic profiling.
Authors: Authors: Janes KA, Wang CC, Holmberg KJ, Cabral K, Brugge JS.
Nat Methods
View full abstract on Pubmed
A structure-guided approach to creating covalent FGFR inhibitors.
Authors: Authors: Zhou W, Hur W, McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS.
Chem Biol
View full abstract on Pubmed
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Authors: Authors: Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
MYC regulation of a "poor-prognosis" metastatic cancer cell state.
Authors: Authors: Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S.
Proc Natl Acad Sci U S A
View full abstract on Pubmed