Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513B

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-3974

In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis.
Authors: Authors: Davidowitz RA, Iwanicki MP, Brugge JS.
J Vis Exp
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Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.
Authors: Authors: Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS.
Cancer Cell
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Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.
Authors: Authors: Leung CT, Brugge JS.
Nature
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Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.
Authors: Authors: Wang L, Brugge JS, Janes KA.
Proc Natl Acad Sci U S A
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Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.
Authors: Authors: Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS.
Genes Dev
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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Authors: Authors: Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG.
Nat Genet
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Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.
Authors: Authors: Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Ince T, Brugge JS.
Cancer Discov
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The myosin-II-responsive focal adhesion proteome: a tour de force?
Authors: Authors: Gallegos L, Ng MR, Brugge JS.
Nat Cell Biol
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Psidin, a conserved protein that regulates protrusion dynamics and cell migration.
Authors: Authors: Kim JH, Cho A, Yin H, Schafer DA, Mouneimne G, Simpson KJ, Nguyen KV, Brugge JS, Montell DJ.
Genes Dev
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Uncovering a tumor suppressor for triple-negative breast cancers.
Authors: Authors: Albeck JG, Brugge JS.
Cell
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