Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513B

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-3974

Chaperone-mediated autophagy degrades mutant p53.
Authors: Authors: Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.
Genes Dev
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Chaperone-mediated autophagy degrades mutant p53.
Authors: Authors: Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.
Genes Dev
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PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells.
Authors: Authors: Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS.
Cancer Cell
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Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.
Authors: Authors: Albeck JG, Mills GB, Brugge JS.
Mol Cell
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Evidence for a multipotent mammary progenitor with pregnancy-specific activity.
Authors: Authors: Kaanta AS, Virtanen C, Selfors LM, Brugge JS, Neel BG.
Breast Cancer Res
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Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.
Authors: Authors: Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS.
Cancer Cell
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Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility.
Authors: Authors: Ng MR, Besser A, Danuser G, Brugge JS.
J Cell Biol
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Q&A: Joan Brugge on empowering post-docs.
Authors: Authors: Brugge J.
Cancer Discov
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Into the deep: Refocusing on 3D.
Authors: Authors: Brugge JS.
Nat Cell Biol
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Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.
Authors: Authors: Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG.
Sci Signal
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