Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Virus-specific RNA species present in the cytoplasm of Rous sarcoma virus-infected chicken cells.
Authors: Authors: Brugge JS, Purchio AF, Erikson RL.
Virology
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Identification of a transformation-specific antigen induced by an avian sarcoma virus.
Authors: Authors: Brugge JS, Erikson RL.
Nature
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Phosphorylated and nonphosphorylated forms of avian sarcoma virus polypeptide p19.
Authors: Authors: Erikson E, Brugge JS, Erikson RL.
Virology
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The role of SV40 gene A in the alteration of microfilaments in transformed cells.
Authors: Authors: Vollet JJ, Brugge JS, Noonan CA, Butel JS.
Exp Cell Res
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Characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40.
Authors: Authors: Noonan CA, Brugge JS, Butel JS.
J Virol
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Role of simian virus 40 gene A function in maintenance of transformation.
Authors: Authors: Brugge JS, Butel JS.
J Virol
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Transformation of primate and rodent cells by temperature-sensitive mutants of SV40.
Authors: Authors: Butel JS, Brugge JS, Noonan CA.
Cold Spring Harb Symp Quant Biol
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Vav GEFs are required for b2 integrin-dependent functions of neutrophils
Authors: Authors: Martinez Gakidis MA, Cullere X, Olson W, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T and Brugge JS
Submitted,
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth
Authors: Authors: Martin S, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS and Leder P
Oncogene, in press,
Bim regulation of lumen formation in mammary epithelial acini is blocked by oncogenes
Authors: Authors: Reginato MJ, Mills KR, Paulus JK, Debnath J, Muthuswamy SK and Brugge JS
Submitted,