Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Morphological revertants of an avian sarcoma virus-transformed mammalian cell line exhibit tumorigenicity and contain pp60src.
Authors: Authors: Lau AF, Krzyzek RA, Brugge JS, Erikson RL, Schollmeyer J, Faras AJ.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product.
Authors: Authors: Collett MS, Erikson E, Purchio AF, Brugge JS, Erikson RL.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Detection of the viral sarcoma gene product in cells infected with various strains of avian sarcoma virus and of a related protein in uninfected chicken cells.
Authors: Authors: Brugge JS, Collett MS, Siddiqui A, Marczynska B, Deinhardt F, Erikson RL.
J Virol
View full abstract on Pubmed
Studies on the structure and function of the avian sarcoma virus transforming gene product.
Authors: Authors: Erikson RL, Brugge JS, Erikson E, Collett MS.
Haematol Blood Transfus
View full abstract on Pubmed
Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product.
Authors: Authors: Collett MS, Brugge JS, Erikson RL.
Cell
View full abstract on Pubmed
Characterization of the avian sarcoma virus protein p60src.
Authors: Authors: Brugge JS, Steinbaugh PJ, Erikson RL.
Virology
View full abstract on Pubmed
Peptide analysis of the transformation-specific antigen from avian sarcoma virus-transformed cells.
Authors: Authors: Brugge J, Erikson E, Collett MS, Erikson RI.
J Virol
View full abstract on Pubmed
Identification of a polypeptide encoded by the avian sarcoma virus src gene.
Authors: Authors: Purchio AF, Erikson E, Brugge JS, Erikson RL.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Antibody to virion structural proteins in mammals bearing avian sarcoma virus-induced tumors.
Authors: Authors: Brugge JS, Erikson E, Erikson RL.
Virology
View full abstract on Pubmed
The distribution of virus-specific RNA in Rous sarcoma virus-induced hamster tumor cells.
Authors: Authors: Brugge JS, Purchio AF, Erikson RL.
Virology
View full abstract on Pubmed