Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.
Authors: Authors: Kremer NE, D'Arcangelo G, Thomas SM, DeMarco M, Brugge JS, Halegoua S.
J Cell Biol
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Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase.
Authors: Authors: Thomas JE, Soriano P, Brugge JS.
Science
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Protein tyrosine phosphorylation and the adhesive functions of platelets.
Authors: Authors: Shattil SJ, Brugge JS.
Curr Opin Cell Biol
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Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.
Authors: Authors: Thomas SM, Hayes M, D'Arcangelo G, Armstrong RC, Meyer BE, Zilberstein A, Brugge JS, Halegoua S.
Mol Cell Biol
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Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation.
Authors: Authors: Lord KA, Abdollahi A, Thomas SM, DeMarco M, Brugge JS, Hoffman-Liebermann B, Liebermann DA.
Mol Cell Biol
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Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.
Authors: Authors: Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS.
Proc Natl Acad Sci U S A
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Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src.
Authors: Authors: Dorai T, Levy JB, Kang L, Brugge JS, Wang LH.
Mol Cell Biol
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Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.
Authors: Authors: Golden A, Brugge JS, Shattil SJ.
J Cell Biol
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Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication.
Authors: Authors: Filson AJ, Azarnia R, Beyer EC, Loewenstein WR, Brugge JS.
Cell Growth Differ
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Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets.
Authors: Authors: Mitchell CA, Jefferson AB, Bejeck BE, Brugge JS, Deuel TF, Majerus PW.
Proc Natl Acad Sci U S A
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