Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Tyrosine phosphorylation in platelets Potential roles in intracellular signal transduction.
Authors: Authors: Clark EA, Brugge JS.
Trends Cardiovasc Med
View full abstract on Pubmed
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.
Authors: Authors: Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG, Schlessinger J, Pawson T, et al.
Nature
View full abstract on Pubmed
Solution structure of the SH3 domain of Src and identification of its ligand-binding site.
Authors: Authors: Yu H, Rosen MK, Shin TB, Seidel-Dugan C, Brugge JS, Schreiber SL.
Science
View full abstract on Pubmed
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.
Authors: Authors: Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS.
J Cell Biol
View full abstract on Pubmed
Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells.
Authors: Authors: Maroney AC, Qureshi SA, Foster DA, Brugge JS.
Oncogene
View full abstract on Pubmed
Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.
Authors: Authors: Seidel-Dugan C, Meyer BE, Thomas SM, Brugge JS.
Mol Cell Biol
View full abstract on Pubmed
Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases.
Authors: Authors: Thomas SM, DeMarco M, D'Arcangelo G, Halegoua S, Brugge JS.
Cell
View full abstract on Pubmed
Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.
Authors: Authors: Huang MM, Indik Z, Brass LF, Hoxie JA, Schreiber AD, Brugge JS.
J Biol Chem
View full abstract on Pubmed
p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets.
Authors: Authors: Cichowski K, McCormick F, Brugge JS.
J Biol Chem
View full abstract on Pubmed
pp60src tyrosine kinase modulates P19 embryonal carcinoma cell fate by inhibiting neuronal but not epithelial differentiation.
Authors: Authors: Schmidt JW, Brugge JS, Nelson WJ.
J Cell Biol
View full abstract on Pubmed