Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.
Authors: Authors: Weng Z, Thomas SM, Rickles RJ, Taylor JA, Brauer AW, Seidel-Dugan C, Michael WM, Dreyfuss G, Brugge JS.
Mol Cell Biol
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Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.
Authors: Authors: Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS.
J Biol Chem
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On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton.
Authors: Authors: Fox JE, Lipfert L, Clark EA, Reynolds CC, Austin CD, Brugge JS.
J Biol Chem
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Increased expression of the src proto-oncogene in hairy cell leukemia and a subgroup of B-cell lymphomas.
Authors: Authors: Lynch SA, Brugge JS, Fromowitz F, Glantz L, Wang P, Caruso R, Viola MV.
Leukemia
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Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src.
Authors: Authors: Thomas JE, Aguzzi A, Soriano P, Wagner EF, Brugge JS.
Oncogene
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Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands.
Authors: Authors: Haimovich B, Lipfert L, Brugge JS, Shattil SJ.
J Biol Chem
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Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells.
Authors: Authors: Weng Z, Taylor JA, Turner CE, Brugge JS, Seidel-Dugan C.
J Biol Chem
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Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK.
Authors: Authors: Huang MM, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil SJ.
J Cell Biol
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New intracellular targets for therapeutic drug design.
Authors: Authors: Brugge JS.
Science
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Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.
Authors: Authors: Clark EA, Brugge JS.
Mol Cell Biol
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