Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513B

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-3974

Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc.
Authors: Authors: Miranti CK, Ohno S, Brugge JS.
J Biol Chem
View full abstract on Pubmed
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth
Authors: Authors: Martin S, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS and Leder P
Oncogene, in press,
Bim regulation of lumen formation in mammary epithelial acini is blocked by oncogenes
Authors: Authors: Reginato MJ, Mills KR, Paulus JK, Debnath J, Muthuswamy SK and Brugge JS
Submitted,
Epidermal growth factor receptor regulation of integrin signaling and cell cycle entry in epithelial cells
Authors: Authors: Miranti CK, Bill HM, Moores SL, Muthuswamy SK, Rao VR and Brugge JS
Journal of Cell Biology, in press,
Vav GEFs are required for b2 integrin-dependent functions of neutrophils
Authors: Authors: Martinez Gakidis MA, Cullere X, Olson W, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T and Brugge JS
Submitted,