Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

A new mutational AKTivation in the PI3K pathway.
Authors: Authors: Brugge J, Hung MC, Mills GB.
Cancer Cell
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Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.
Authors: Authors: Schmelzle T, Mailleux AA, Overholtzer M, Carroll JS, Solimini NL, Lightcap ES, Veiby OP, Brugge JS.
Proc Natl Acad Sci U S A
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BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.
Authors: Authors: Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS.
Dev Cell
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p63, cell adhesion and survival.
Authors: Authors: Carroll DK, Brugge JS, Attardi LD.
Cell Cycle
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SePARating polarity and proliferation in ErbB2 oncogenesis.
Authors: Authors: Walker SJ, Brugge JS.
Nat Cell Biol
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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon.
Authors: Authors: Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA.
Proc Natl Acad Sci U S A
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p63 regulates an adhesion programme and cell survival in epithelial cells.
Authors: Authors: Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW.
Nat Cell Biol
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An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand.
Authors: Authors: Wilsbacher JL, Moores SL, Brugge JS.
Cell Commun Signal
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Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.
Authors: Authors: Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS.
Immunity
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Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer.
Authors: Authors: Witt AE, Hines LM, Collins NL, Hu Y, Gunawardane RN, Moreira D, Raphael J, Jepson D, Koundinya M, Rolfs A, Taron B, Isakoff SJ, Brugge JS, LaBaer J.
J Proteome Res
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