Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513B

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-3974

An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand.
Authors: Authors: Wilsbacher JL, Moores SL, Brugge JS.
Cell Commun Signal
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Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.
Authors: Authors: Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS.
Immunity
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Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer.
Authors: Authors: Witt AE, Hines LM, Collins NL, Hu Y, Gunawardane RN, Moreira D, Raphael J, Jepson D, Koundinya M, Rolfs A, Taron B, Isakoff SJ, Brugge JS, LaBaer J.
J Proteome Res
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Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.
Authors: Authors: Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS.
J Cell Biol
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Novel role for PDEF in epithelial cell migration and invasion.
Authors: Authors: Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS.
Cancer Res
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Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.
Authors: Authors: Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS.
Cancer Res
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Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells.
Authors: Authors: Yan SR, Joseph RR, Rosen K, Reginato MJ, Jackson A, Allaire N, Brugge JS, Jobin C, Stadnyk AW.
Oncogene
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Modelling glandular epithelial cancers in three-dimensional cultures.
Authors: Authors: Debnath J, Brugge JS.
Nat Rev Cancer
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G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression.
Authors: Authors: Collins NL, Reginato MJ, Paulus JK, Sgroi DC, Labaer J, Brugge JS.
Mol Cell Biol
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Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.
Authors: Authors: Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS.
Mol Cell Biol
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