Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Identification of genes that regulate epithelial cell migration using an siRNA screening approach.
Authors: Authors: Simpson KJ, Selfors LM, Bui J, Reynolds A, Leake D, Khvorova A, Brugge JS.
Nat Cell Biol
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Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1.
Authors: Authors: Melani M, Simpson KJ, Brugge JS, Montell D.
Curr Biol
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[Entosis, a cell death process related to cell cannibalism between tumor cells].
Authors: Authors: Mailleux AA, Overholtzer M, Brugge JS.
Med Sci (Paris)
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Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models.
Authors: Authors: Mailleux AA, Overholtzer M, Brugge JS.
Cell Cycle
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Circulating colony stimulating factor-1 and breast cancer risk.
Authors: Authors: Tamimi RM, Brugge JS, Freedman ML, Miron A, Iglehart JD, Colditz GA, Hankinson SE.
Cancer Res
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IL-6 involvement in epithelial cancers.
Authors: Authors: Schafer ZT, Brugge JS.
J Clin Invest
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A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.
Authors: Authors: Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS.
Cell
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Engineering tumors with 3D scaffolds.
Authors: Authors: Fischbach C, Chen R, Matsumoto T, Schmelzle T, Brugge JS, Polverini PJ, Mooney DJ.
Nat Methods
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Tensins: a new switch in cell migration.
Authors: Authors: Mouneimne G, Brugge JS.
Dev Cell
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Common effector processing mediates cell-specific responses to stimuli.
Authors: Authors: Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA.
Nature
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