Joan Brugge, Ph.D.

Joan Brugge, Ph.D.

Louise Foote Pfeiffer Professor of Cell Biology (HMS)
Director of the Ludwig Center at Harvard

Joan Brugge, Ph.D., received her Ph.D. in virology from Baylor College of Medicine, and was a postdoctoral researcher at the University of Colorado Medical Center. After professorships at SUNY, Stony Brook and the University of Pennsylvania, where she was an HHMI investigator, she became the Scientific Director and Senior VP at ARIAD Pharmaceuticals. She returned to academia as Professor of Cell Biology at HMS in 1997, and was Chair of the department from 2004-2014. She became Co-Director of the Ludwig Center at Harvard in 2014. She currently sits on the Scientific Advisory Board of the Allen Institute of Cell Sciences.

The Brugge laboratory is investigating the cellular processes and pathways that are involved in normal morphogenesis of epithelial tissues as well as those involved in the initiation and progression of epithelial tumors.

Harvard Medical School

Dept. of Cell Biology, C-513

240 Longwood Avenue

Boston, MA 02115

Tumor self-seeding: bidirectional flow of tumor cells.
Authors: Authors: Leung CT, Brugge JS.
Cell
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Mutant p53 drives invasion by promoting integrin recycling.
Authors: Authors: Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH.
Cell
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A stiff blow from the stroma: collagen crosslinking drives tumor progression.
Authors: Authors: Ng MR, Brugge JS.
Cancer Cell
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YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.
Authors: Authors: Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA.
Nat Cell Biol
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Activity of the multikinase inhibitor dasatinib against ovarian cancer cells.
Authors: Authors: Konecny GE, Glas R, Dering J, Manivong K, Qi J, Finn RS, Yang GR, Hong KL, Ginther C, Winterhoff B, Gao G, Brugge J, Slamon DJ.
Br J Cancer
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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.
Authors: Authors: Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS.
Nature
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YB-1 translational control of epithelial-mesenchyme transition.
Authors: Authors: Mouneimne G, Brugge JS.
Cancer Cell
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Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival.
Authors: Authors: Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS.
Cancer Res
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Transcriptional regulation of metastatic [Id]entity by KLF17.
Authors: Authors: Iwanicki MP, Brugge JS.
Genome Biol
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The cell biology of cell-in-cell structures.
Authors: Authors: Overholtzer M, Brugge JS.
Nat Rev Mol Cell Biol
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