Headshot of Ed Chouchani

Edward Chouchani, Ph.D.

Professor of Cancer Biology (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
HHMI Investigator

Edward Chouchani, Ph.D., joined the faculty of Harvard Medical School in 2017. He received his Ph.D. in Biological Sciences at the University of Cambridge and MRC Mitochondrial Biology Unit. He then performed postdoctoral research at the Dana-Farber Cancer Institute and Harvard Medical School. In 2024, he became a Howard Hughes Medical Institute Investigator.

Research in the Chouchani Lab focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signaling, and their dysfunction is key in the pathology of metabolic disease.  The Chouchani Lab combines mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6212

360 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-632-3281

Lab Fax: 617-632-5363

The human zinc-binding cysteine proteome.
Authors: Authors: Burger N, Mittenbühler MJ, Xiao H, Shin S, Wei SM, Henze EK, Schindler S, Mehravar S, Wood DM, Petrocelli JJ, Sun Y, Sprenger HG, Latorre-Muro P, Smythers AL, Bozi LHM, Darabedian N, Zhu Y, Seo HS, Dhe-Paganon S, Che J, Chouchani ET.
Cell
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A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense.
Authors: Authors: Chang RB, Toyoda HC, Hobbs SJ, Richmond-Buccola D, Wein T, Burger N, Chouchani ET, Sorek R, Kranzusch PJ.
bioRxiv
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A covalent creatine kinase inhibitor ablates glioblastoma migration and sensitizes tumors to oxidative stress.
Authors: Authors: Katz JL, Geng Y, Billingham LK, Sadagopan NS, DeLay SL, Subbiah J, Chia TY, McManus G, Wei C, Wang H, Lin H, Silvers C, Boland LK, Wang S, Wan H, Hou D, Vázquez-Cervantes GI, Arjmandi T, Shaikh ZH, Zhang P, Ahmed AU, Tiek DM, Lee-Chang C, Chouchani ET, Miska J.
Sci Rep
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Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.
Authors: Authors: Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer SM, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma AK, Balaz M, Wolfrum C, Spiegelman BM.
Cell Metab
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Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology.
Authors: Authors: Barnett D, Zimmer TS, Booraem C, Palaguachi F, Meadows SM, Xiao H, Chouchani ET, Orr AG, Orr AL.
bioRxiv
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Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
Authors: Authors: Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM.
bioRxiv
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A new era of cysteine proteomics - Technological advances in thiol biology.
Authors: Authors: Burger N, Chouchani ET.
Curr Opin Chem Biol
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Monocarboxylate transporters facilitate succinate uptake into brown adipocytes.
Authors: Authors: Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, Smith A, Ordonez M, Laznik-Bogoslavski D, Rothstein JD, Mills EL, Chouchani ET.
Nat Metab
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A comprehensive landscape of the zinc-regulated human proteome.
Authors: Authors: Burger N, Mittenbühler MJ, Xiao H, Shin S, Bozi LHM, Wei S, Sprenger HG, Sun Y, Zhu Y, Darabedian N, Petrocelli JJ, Muro PL, Che J, Chouchani ET.
bioRxiv
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Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry.
Authors: Authors: Sarott RC, You I, Li YD, Toenjes ST, Donovan KA, Seo P, Ordonez M, Byun WS, Hassan MM, Wachter F, Chouchani ET, Slabicki M, Fischer ES, Ebert BL, Hinshaw SM, Gray NS.
J Am Chem Soc
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