Edward Chouchani
Edward Chouchani, Ph.D.
Associate Professor of Cancer Biology (Dana-Farber Cancer Institute)
Associate Professor of Cell Biology (HMS)

Edward Chouchani, Ph.D., joined the faculty of Harvard Medical School as an Assistant Professor of Cell Biology in 2017. He received his Ph.D. in Biological Sciences at the University of Cambridge and MRC Mitochondrial Biology Unit. He then performed postdoctoral research at the Dana-Farber Cancer Institute and Harvard Medical School.

Research in the Chouchani Lab focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signaling, and their dysfunction is key in the pathology of metabolic disease.  The Chouchani Lab combines mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6212

360 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-632-3281

Lab Fax: 617-632-5363

Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel.
Authors: Authors: Murphy MP, Chouchani ET.
Nat Chem Biol
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Correction: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Authors: Authors: Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L.
J Exp Med
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Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Authors: Authors: Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L.
J Exp Med
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Logic and mechanisms of metabolite signalling.
Authors: Authors: Chouchani ET.
Nat Rev Endocrinol
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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Authors: Authors: Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET.
Cell Metab
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Measurement of Futile Creatine Cycling Using Respirometry.
Authors: Authors: Rahbani JF, Chouchani ET, Spiegelman BM, Kazak L.
Methods Mol Biol
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Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.
Authors: Authors: Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN.
Cell Rep
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Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.
Authors: Authors: Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR.
Nature
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Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease.
Authors: Authors: Guillot-Sestier MV, Araiz AR, Mela V, Gaban AS, O'Neill E, Joshi L, Chouchani ET, Mills EL, Lynch MA.
Commun Biol
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UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Authors: Authors: Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET.
Nat Metab
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