Headshot of Ed Chouchani

Edward Chouchani, Ph.D.

Associate Professor of Cancer Biology (Dana-Farber Cancer Institute)
Associate Professor of Cell Biology (HMS)

Edward Chouchani, Ph.D., joined the faculty of Harvard Medical School as an Assistant Professor of Cell Biology in 2017. He received his Ph.D. in Biological Sciences at the University of Cambridge and MRC Mitochondrial Biology Unit. He then performed postdoctoral research at the Dana-Farber Cancer Institute and Harvard Medical School.

Research in the Chouchani Lab focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signaling, and their dysfunction is key in the pathology of metabolic disease.  The Chouchani Lab combines mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6212

360 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-632-3281

Lab Fax: 617-632-5363

A comprehensive landscape of the zinc-regulated human proteome.
Authors: Authors: Burger N, Mittenbühler MJ, Xiao H, Shin S, Bozi LHM, Wei S, Sprenger HG, Sun Y, Zhu Y, Darabedian N, Petrocelli JJ, Muro PL, Che J, Chouchani ET.
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Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry.
Authors: Authors: Sarott RC, You I, Li YD, Toenjes ST, Donovan KA, Seo P, Ordonez M, Byun WS, Hassan MM, Wachter F, Chouchani ET, Slabicki M, Fischer ES, Ebert BL, Hinshaw SM, Gray NS.
J Am Chem Soc
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Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.
Authors: Authors: Darabedian N, Ji W, Fan M, Lin S, Seo HS, Vinogradova EV, Yaron TM, Mills EL, Xiao H, Senkane K, Huntsman EM, Johnson JL, Che J, Cantley LC, Cravatt BF, Dhe-Paganon S, Stegmaier K, Zhang T, Gray NS, Chouchani ET.
Nat Chem Biol
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Lactate regulates cell cycle by remodelling the anaphase promoting complex.
Authors: Authors: Liu W, Wang Y, Bozi LHM, Fischer PD, Jedrychowski MP, Xiao H, Wu T, Darabedian N, He X, Mills EL, Burger N, Shin S, Reddy A, Sprenger HG, Tran N, Winther S, Hinshaw SM, Shen J, Seo HS, Song K, Xu AZ, Sebastian L, Zhao JJ, Dhe-Paganon S, Che J, Gygi SP, Arthanari H, Chouchani ET.
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Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.
Authors: Authors: Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM.
Cell Metab
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Monocarboxylate transporters facilitate succinate uptake into brown adipocytes.
Authors: Authors: Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, Smith A, Mills EL, Chouchani ET.
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Gasdermin D pore-forming activity is redox-sensitive.
Authors: Authors: Devant P, Boršic E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovic I, Evavold CL, Kagan JC.
Cell Rep
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Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics.
Authors: Authors: Campos JC, Marchesi Bozi LH, Krum B, Grassmann Bechara LR, Ferreira ND, Arini GS, Albuquerque RP, Traa A, Ogawa T, van der Bliek AM, Beheshti A, Chouchani ET, Van Raamsdonk JM, Blackwell TK, Ferreira JCB.
Proc Natl Acad Sci U S A
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Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
Authors: Authors: Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET.
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Career pathways, part 9.
Authors: Authors: Mills EL, Chouchani ET.
Nat Metab
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