Headshot of Ed Chouchani

Edward Chouchani, Ph.D.

Associate Professor of Cancer Biology (Dana-Farber Cancer Institute)
Associate Professor of Cell Biology (HMS)

Edward Chouchani, Ph.D., joined the faculty of Harvard Medical School as an Assistant Professor of Cell Biology in 2017. He received his Ph.D. in Biological Sciences at the University of Cambridge and MRC Mitochondrial Biology Unit. He then performed postdoctoral research at the Dana-Farber Cancer Institute and Harvard Medical School.

Research in the Chouchani Lab focuses on deciphering molecular mechanisms that drive metabolic disease, and using this information to develop targeted therapeutic strategies.  Mitochondria are critical hubs for metabolic signaling, and their dysfunction is key in the pathology of metabolic disease.  The Chouchani Lab combines mass spectrometry and targeted pharmacological approaches in vivo to understand how mitochondrial redox metabolism controls physiology in clinically informative mouse models of obesity and diabetes.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6212

360 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-632-3281

Lab Fax: 617-632-5363

Monocarboxylate transporters facilitate succinate uptake into brown adipocytes.
Authors: Authors: Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, Smith A, Mills EL, Chouchani ET.
bioRxiv
View full abstract on Pubmed
Gasdermin D pore-forming activity is redox-sensitive.
Authors: Authors: Devant P, Boršic E, Ngwa EM, Xiao H, Chouchani ET, Thiagarajah JR, Hafner-Bratkovic I, Evavold CL, Kagan JC.
Cell Rep
View full abstract on Pubmed
Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics.
Authors: Authors: Campos JC, Marchesi Bozi LH, Krum B, Grassmann Bechara LR, Ferreira ND, Arini GS, Albuquerque RP, Traa A, Ogawa T, van der Bliek AM, Beheshti A, Chouchani ET, Van Raamsdonk JM, Blackwell TK, Ferreira JCB.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
Authors: Authors: Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET.
Cell
View full abstract on Pubmed
Career pathways, part 9.
Authors: Authors: Mills EL, Chouchani ET.
Nat Metab
View full abstract on Pubmed
Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
Authors: Authors: Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y.
Nature
View full abstract on Pubmed
Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel.
Authors: Authors: Murphy MP, Chouchani ET.
Nat Chem Biol
View full abstract on Pubmed
Correction: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Authors: Authors: Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L.
J Exp Med
View full abstract on Pubmed
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Authors: Authors: Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L.
J Exp Med
View full abstract on Pubmed
Logic and mechanisms of metabolite signalling.
Authors: Authors: Chouchani ET.
Nat Rev Endocrinol
View full abstract on Pubmed