Daniel Finley, Ph.D.

Daniel Finley, Ph.D.

Professor of Cell Biology (HMS)
C-404B
617-432-3492
Finley Lab

Dan Finley, Ph.D., received his undergraduate degree from Harvard University in biochemistry, and his graduate degree from MIT, with a focus on molecular biology. He stayed at MIT for his postdoctoral training before joining the Department of Cell Biology at HMS in 1988. He also currently sits on the Scientific Advisory Boards of Proteostasis and X-Chem Pharmaceuticals, and is a consultant for Genentech.

The Finley lab is interested in the ubiquitin-proteasome pathway and related regulatory systems. Specific topics include the mechanism of the proteasome, ubiquitin-like proteins, antizyme, and nonproteolytic functions of ubiquitination.

Harvard Medical School

Dept of Cell Biology, C-404B

240 Longwood Avenue

Boston, MA 02115

Lab Phone: 617-432-3492

Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.
Authors: Authors: Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D.
Cell
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Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology.
Authors: Authors: Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP.
Nat Cell Biol
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Proteasome-associated proteins: regulation of a proteolytic machine.
Authors: Authors: Schmidt M, Hanna J, Elsasser S, Finley D.
Biol Chem
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Delivery of ubiquitinated substrates to protein-unfolding machines.
Authors: Authors: Elsasser S, Finley D.
Nat Cell Biol
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Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation.
Authors: Authors: Shang F, Deng G, Liu Q, Guo W, Haas AL, Crosas B, Finley D, Taylor A.
J Biol Chem
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The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle.
Authors: Authors: Schmidt M, Haas W, Crosas B, Santamaria PG, Gygi SP, Walz T, Finley D.
Nat Struct Mol Biol
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Characterization of the proteasome using native gel electrophoresis.
Authors: Authors: Elsasser S, Schmidt M, Finley D.
Methods Enzymol
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Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast.
Authors: Authors: Leggett DS, Glickman MH, Finley D.
Methods Mol Biol
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Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.
Authors: Authors: Wilkinson CR, Dittmar GA, Ohi MD, Uetz P, Jones N, Finley D.
Curr Biol
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Varshavsky's contributions.
Authors: Authors: Baumeister W, Bachmair A, Chau V, Cohen R, Coffino P, Demartino G, Deshaies R, Dohmen J, Emr S, Finley D, Hampton R, Hill C, Hochstrasser M, Huber R, Jackson P, Jentsch S, Johnson E, Kwon YT, Pagano M, Pickart C, Rechsteiner M, Scheffner M, Sommer T, Tansey W, Tyers M, Vierstra R, Weissman A, Wilkinson KD, Wolf D.
Science
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