Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Mechanism of futile creatine cycling in thermogenesis.
Authors: Authors: Kazak L, Spiegelman BM.
Am J Physiol Endocrinol Metab
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Obesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Authors: Authors: Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS.
Cell Metab
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A Plasma Protein Network Regulates PM20D1 and N-Acyl Amino Acid Bioactivity.
Authors: Authors: Kim JT, Jedrychowski MP, Wei W, Fernandez D, Fischer CR, Banik SM, Spiegelman BM, Long JZ.
Cell Chem Biol
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Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo.
Authors: Authors: Estell EG, Le PT, Vegting Y, Kim H, Wrann C, Bouxsein ML, Nagano K, Baron R, Spiegelman BM, Rosen CJ.
Elife
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CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
Authors: Authors: Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S.
Cell
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Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
Authors: Authors: Baht GS, Bareja A, Lee DE, Rao RR, Huang R, Huebner JL, Bartlett DB, Hart CR, Gibson JR, Lanza IR, Kraus VB, Gregory SG, Spiegelman BM, White JP.
Nat Metab
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Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
Authors: Authors: Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM.
Proc Natl Acad Sci U S A
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Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
Authors: Authors: Baht GS, Bareja A, Lee DE, Rao RR, Huang R, Huebner JL, Bartlett DB, Hart CR, Gibson JR, Lanza IR, Kraus VB, Gregory SG, Spiegelman BM, White JP.
Nat Metab
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?d T cells and adipocyte IL-17RC control fat innervation and thermogenesis.
Authors: Authors: Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM.
Nature
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Confounding issues in the "humanized" BAT of mice.
Authors: Authors: Kajimura S, Spiegelman BM.
Nat Metab
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