Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Fat and beyond: the diverse biology of PPARgamma.
Authors: Authors: Tontonoz P, Spiegelman BM.
Annu Rev Biochem
View full abstract on Pubmed
Cell Differentiation.
Authors: Authors: Farmer SR, Spiegelman BM.
Curr Opin Cell Biol
View full abstract on Pubmed
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.
Authors: Authors: Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM.
J Clin Invest
View full abstract on Pubmed
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.
Authors: Authors: Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM.
J Biol Chem
View full abstract on Pubmed
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Authors: Authors: Jäger S, Handschin C, St-Pierre J, Spiegelman BM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Transcriptional control of brown fat determination by PRDM16.
Authors: Authors: Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM.
Cell Metab
View full abstract on Pubmed
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha.
Authors: Authors: Rohas LM, St-Pierre J, Uldry M, Jäger S, Handschin C, Spiegelman BM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Synergy between PPARgamma ligands and platinum-based drugs in cancer.
Authors: Authors: Girnun GD, Naseri E, Vafai SB, Qu L, Szwaya JD, Bronson R, Alberta JA, Spiegelman BM.
Cancer Cell
View full abstract on Pubmed
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
Authors: Authors: Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM.
Genes Dev
View full abstract on Pubmed
Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.
Authors: Authors: Spiegelman BM.
Novartis Found Symp
View full abstract on Pubmed