Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130.
Authors: Authors: Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM.
J Biol Chem
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Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
Authors: Authors: Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, Demetri G, Spiegelman BM, Wong KK.
Clin Cancer Res
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A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.
Authors: Authors: Walkey CJ, Spiegelman BM.
J Biol Chem
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Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype.
Authors: Authors: Wenz T, Diaz F, Spiegelman BM, Moraes CT.
Cell Metab
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PRDM16 controls a brown fat/skeletal muscle switch.
Authors: Authors: Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM.
Nature
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The role of exercise and PGC1alpha in inflammation and chronic disease.
Authors: Authors: Handschin C, Spiegelman BM.
Nature
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Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Authors: Authors: Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM.
Genes Dev
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Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake.
Authors: Authors: Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM, Stevenson SC, Rangwala SM.
J Appl Physiol (1985)
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Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.
Authors: Authors: Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM.
Proc Natl Acad Sci U S A
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HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.
Authors: Authors: Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM.
Nature
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