Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

SnapShot: Regulation and biology of PGC-1a.
Authors: Authors: Jannig PR, Dumesic PA, Spiegelman BM, Ruas JL.
Cell
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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Authors: Authors: Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET.
Cell Metab
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Measurement of Futile Creatine Cycling Using Respirometry.
Authors: Authors: Rahbani JF, Chouchani ET, Spiegelman BM, Kazak L.
Methods Mol Biol
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Author Correction: Exercise hormone irisin is a critical regulator of cognitive function.
Authors: Authors: Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, Christie BR, Schmider AB, Soberman RJ, Besnard A, Jedrychowski MP, Kim H, Tu H, Kim E, Choi SH, Tanzi RE, Spiegelman BM, Wrann CD.
Nat Metab
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Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis.
Authors: Authors: Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio MA, Sahai T, Dou FY, Roche AM, Carcamo-Orive I, Knowles JW, Wabitsch M, Appel EA, Maikawa CL, Camporez JP, Shulman GI, Tsai L, Rosen ED, Gardner CD, Spiegelman BM, Svensson KJ.
Cell Metab
View full abstract on Pubmed
Exercise hormone irisin is a critical regulator of cognitive function.
Authors: Authors: Islam MR, Valaris S, Young MF, Haley EB, Luo R, Bond SF, Mazuera S, Kitchen RR, Caldarone BJ, Bettio LEB, Christie BR, Schmider AB, Soberman RJ, Besnard A, Jedrychowski MP, Kim H, Tu H, Kim E, Choi SH, Tanzi RE, Spiegelman BM, Wrann CD.
Nat Metab
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Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Authors: Authors: Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM.
Nature
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Author Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis.
Authors: Authors: Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM.
Nature
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Creatine kinase B controls futile creatine cycling in thermogenic fat.
Authors: Authors: Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, <a href="https://connects.catalyst.harvard.edu/Profiles/profile/1250277">Jedrychowski MP</a>, Vergnes L, Reue K, <a href="https://connects.catalyst.harvard.edu/Profiles/profile/1254750">Spiegelman BM</a>, Kazak L.
Nature
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No evidence for brown adipose tissue activation after creatine supplementation in adult vegetarians.
Authors: Authors: Connell NJ, Doligkeit D, Andriessen C, Kornips-Moonen E, Bruls YMH, Schrauwen-Hinderling VB, van de Weijer T, van Marken-Lichtenbelt WD, Havekes B, Kazak L, Spiegelman BM, Hoeks J, Schrauwen P.
Nat Metab
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