Bruce Spiegelman

Bruce Spiegelman, Ph.D.

Stanley J. Korsmeyer Professor of Cell Biology and Medicine (Dana-Farber Cancer Institute)
Professor of Cell Biology (HMS)
LC-6214
617-632-3567
Spiegelman Lab

Bruce Spiegelman, Ph.D. received a B.S. from the College of William and Mary and his doctorate from Princeton University. His postdoctoral training was at MIT, and he was hired to join the faculty at Harvard Medical School and the Dana-Farber Cancer Institute in 1982. Dr. Spiegelman was elected to the National Academy of Sciences, National Academy of Medicine and is a Foreign Associate of EMBO.

The Spiegelman laboratory is centered on the molecular basis of energy homeostasis and tissue development, using adipogenesis and muscle as the primary model systems. This includes the biochemical mechanisms of metabolic diseases, especially obesity, insulin-resistant diabetes (type 2) and muscle diseases. In addition, we have a major interest in suppressing cancer cell growth by stimulating pathways of altered cell metabolism and DNA repair.

Dana Farber Cancer Institute

Dept. of Cell Biology, LC-6214

360 Longwood Avenue

Boston, MA 02115

Lab telephone: 617-632-3567

Lab fax: 617-582-7176

Faculty Assistant

Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner.
Authors: Authors: Shimonty A, Pin F, Prideaux M, Peng G, Huot JR, Kim H, Rosen CJ, Spiegelman BM, Bonewald LF.
bioRxiv
View full abstract on Pubmed
Irisin Enhances Mitochondrial Function in Osteoclast Progenitors during Differentiation.
Authors: Authors: Estell E, Ichikawa T, Giffault P, Bonewald L, Spiegelman B, Rosen C.
Biomedicines
View full abstract on Pubmed
Regulatory T cells shield muscle mitochondria from interferon-?-mediated damage to promote the beneficial effects of exercise.
Authors: Authors: Langston PK, Sun Y, Ryback BA, Mueller AL, Spiegelman BM, Benoist C, Mathis D.
Sci Immunol
View full abstract on Pubmed
Irisin reduces amyloid-ß by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling.
Authors: Authors: Kim E, Kim H, Jedrychowski MP, Bakiasi G, Park J, Kruskop J, Choi Y, Kwak SS, Quinti L, Kim DY, Wrann CD, Spiegelman BM, Tanzi RE, Choi SH.
Neuron
View full abstract on Pubmed
REPTOR and CREBRF encode key regulators of muscle energy metabolism.
Authors: Authors: Saavedra P, Dumesic PA, Hu Y, Filine E, Jouandin P, Binari R, Wilensky SE, Rodiger J, Wang H, Chen W, Liu Y, Spiegelman BM, Perrimon N.
Nat Commun
View full abstract on Pubmed
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90a.
Authors: Authors: A M, Wales TE, Zhou H, Draga-Coleta SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang ZF, Jedrychowski MP, Seo HS, Song K, Xu AZ, Sebastian L, Gygi SP, Arthanari H, Dhe-Paganon S, Griffin PR, Engen JR, Spiegelman BM.
Mol Cell
View full abstract on Pubmed
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.
Authors: Authors: Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM.
Cell Metab
View full abstract on Pubmed
RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1a.
Authors: Authors: Dumesic PA, Wilensky SE, Bose S, Van Vranken JG, Gygi SP, Spiegelman BM.
bioRxiv
View full abstract on Pubmed
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
Authors: Authors: Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET.
Cell
View full abstract on Pubmed
Amelioration of pathologic a-synuclein-induced Parkinson's disease by irisin.
Authors: Authors: Kam TI, Park H, Chou SC, Van Vranken JG, Mittenbühler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder A, Karuppagounder SS, Wrann CD, Dawson VL, Spiegelman BM, Dawson TM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed