Adrian Salic

Adrian Salic, Ph.D.

Professor of Cell Biology (HMS)
LHRRB 401A
617-432-6341
Salic Lab

Adrian Salic, Ph.D. was appointed Assistant Professor of Cell Biology in 2005, after completing his postdoctoral research in the Department of Systems Biology at Harvard Medical School. He received his PhD from Harvard University in 2000. His development of novel tools to detect DNA and RNA synthesis resulted in the creation of the commerically-available "Click-iT" EdU and EU kits that are now widely used by labs around the world.

The Salic lab studies biochemical and cellular mechanisms involved in signal transduction through the Hedgehog signaling pathway. We also develop and apply new chemical technologies to study the cell biology of lipids.

Harvard Medical School

Dept. of Cell Biology, LHRRB 401A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6341

Lab fax: 617-432-1190

Haematopoietic stem cells require a highly regulated protein synthesis rate.
Authors: Authors: Signer RA, Magee JA, Salic A, Morrison SJ.
Nature
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Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.
Authors: Authors: Nedelcu D, Liu J, Xu Y, Jao C, Salic A.
Nat Chem Biol
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Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.
Authors: Authors: Tukachinsky H, Kuzmickas RP, Jao CY, Liu J, Salic A.
Cell Rep
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Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin.
Authors: Authors: Liu J, Xu Y, Stoleru D, Salic A.
Proc Natl Acad Sci U S A
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A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts.
Authors: Authors: Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E.
J Biomol Screen
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Processing and turnover of the Hedgehog protein in the endoplasmic reticulum.
Authors: Authors: Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A.
J Cell Biol
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Small-molecule inhibition of Wnt signaling through activation of casein kinase 1a.
Authors: Authors: Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E.
Nat Chem Biol
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A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.
Authors: Authors: Tukachinsky H, Lopez LV, Salic A.
J Cell Biol
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Metabolic labeling and direct imaging of choline phospholipids in vivo.
Authors: Authors: Jao CY, Roth M, Welti R, Salic A.
Proc Natl Acad Sci U S A
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Exploring RNA transcription and turnover in vivo by using click chemistry.
Authors: Authors: Jao CY, Salic A.
Proc Natl Acad Sci U S A
View full abstract on Pubmed