Adrian Salic

Adrian Salic, Ph.D.

Professor of Cell Biology (HMS)
LHRRB 401A
617-432-6341
Salic Lab

Adrian Salic, Ph.D. was appointed Assistant Professor of Cell Biology in 2005, after completing his postdoctoral research in the Department of Systems Biology at Harvard Medical School. He received his PhD from Harvard University in 2000. His development of novel tools to detect DNA and RNA synthesis resulted in the creation of the commerically-available "Click-iT" EdU and EU kits that are now widely used by labs around the world.

The Salic lab studies biochemical and cellular mechanisms involved in signal transduction through the Hedgehog signaling pathway. We also develop and apply new chemical technologies to study the cell biology of lipids.

Harvard Medical School

Dept. of Cell Biology, LHRRB 401A

240 Longwood Avenue

Boston, MA 02115

Lab phone: 617-432-6341

Lab fax: 617-432-1190

Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens.
Authors: Authors: de Almeida Magalhaes T, Liu J, Chan C, Borges KS, Zhang J, Kane AJ, Wierbowski BM, Ge Y, Liu Z, Mannam P, Zeve D, Weiss R, Breault DT, Huang P, Salic A.
Dev Cell
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Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity.
Authors: Authors: Quek RT, Hardy KS, Walker SG, Nguyen DT, de Almeida Magalhães T, Salic A, Gopalakrishnan SM, Silver PA, Mitchison TJ.
ACS Chem Biol
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Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma.
Authors: Authors: de Almeida Magalhães T, Alencastro Veiga Cruzeiro G, Ribeiro de Sousa G, Englinger B, Fernando Peinado Nagano L, Ancliffe M, Rodrigues da Silva K, Jiang L, Gojo J, Cherry Liu Y, Carline B, Kuchibhotla M, Pinto Saggioro F, Kazue Nagahashi Marie S, Mieko Oba-Shinjo S, Andres Yunes J, Gomes de Paula Queiroz R, Alberto Scrideli C, Endersby R, Filbin MG, Silva Borges K, Salic A, Gonzaga Tone L, Valera ET.
Neuro Oncol
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Hedgehog pathway modulation by glypican 3-conjugated heparan sulfate.
Authors: Authors: Liu YC, Wierbowski BM, Salic A.
J Cell Sci
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Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.
Authors: Authors: Huang P, Wierbowski BM, Lian T, Chan C, García-Linares S, Jiang J, Salic A.
Dev Cell
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Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release.
Authors: Authors: Li W, Wang L, Wierbowski BM, Lu M, Dong F, Liu W, Li S, Wang P, Salic A, Gong X.
Nat Commun
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Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations.
Authors: Authors: Petrov K, de Almeida Magalhaes T, Salic A.
Proc Natl Acad Sci U S A
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Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand.
Authors: Authors: Wierbowski BM, Petrov K, Aravena L, Gu G, Xu Y, Salic A.
Dev Cell
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Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway.
Authors: Authors: Petrov K, Wierbowski BM, Liu J, Salic A.
Dev Cell
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Structural Basis of Smoothened Activation in Hedgehog Signaling.
Authors: Authors: Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A.
Cell
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