• 2022-2023
    DATE SPEAKER LAB TALK TITLE
    Sep. 7, 2022 Mahtab Dastpak Reed Role of the Essential Splicing Factor SF3B1 in Normal and Neoplastic Hematopoieses
    Sep. 14, 2022 Conor Ronayne Puigserver Mitochondrial Ribosome Signaling and Survival Mechanisms in Mitochondrial Disease
    Sep. 28, 2022 Anand Saminathan Kirchhausen How Antisense Oligonucleotides Enter Cells
    Oct. 5, 2022 Conghui Yao Haigis Untargeted Metabolomics Reveals Novel Metabolic Markers for T Cell Activation
    Oct. 26, 2022 Yuan Gao Rapoport Protein Import into Peroxisomes Occurs Through a Nuclear Pore-like Phase
    Nov. 2, 2022 Kevin Dong Gygi Phenotypic Screening with Cysteine-targeting Electrophiles to Discover Proteasome
    Nov. 16, 2022 Narek Darabedian Chouchani Development of a First in Class Inhibitor of Creatine Kinases
    Nov. 30, 2022 Sam Sedor Shao Quality Control of Orphan Ribosomal Subunit Proteins
    Dec. 7, 2022 Mu A Spiegelman Irisin Acts Through its Integrin Receptor in a Novel Two-Step Process
    Dec. 14, 2022 Anan Chen Salic Exploring the Roles of Double-Membrane Vesicles (DMVs) During Coronavirus Infection
    Jan. 18, 2023 Jon Markert Farnung Characterizing H3K36me3 deposition during transcription elongation
    Jan. 25, 2023 Pruthvi Gowda Danial Remodeling lipid metabolism for therapeutic differentiation of oncohistone gliomas
    Feb. 15, 2023 Stamatis Papathanasiou Pellman Mitotic Errors as a novel source of Epigenetic Instability
    Feb. 22, 2023 Kelsey Hickey Harper Quantitative Mapping of the Autophagic Cargo during Nutrient Stress Reveals Membrane Receptors for Golgiphagy
    Mar. 1, 2023 Ngan Phan Lee Mechanism of translation repression mediated by elF3
    Mar. 15, 2023 Mike Schappe Liberles Neural-epithelial coding of airway senses
    Mar. 29, 2023 Yann Cormerais Manning Defining in vivo the role of PI3K-mTORC1 signaling in the regulation of systemic glucose metabolism
    Apr. 5, 2023 Alba Rodriguez Meira Bernstein Developing a molecular toolkit to study epigenetic evolution in cancer
    Apr. 12, 2023 Stefan Niekamp Subramanian Polycomb repressive complex 1 composition and nucleosomal scaffold properties determine extend of chromatin condensation
    Apr. 26, 2023 Valentina Rossio King Discovery of new deubiquitylating enzyme substrates in Xenopus egg extract
    May 3, 2023 Jared Johnson Cantley Intrinsic substrate specificity of the human protein tyrosine kinome
    May 10, 2023 Deyang Yu Puigserver Lysosomal cyst(e)ine regulates melanoma, melanoma dedifferentiation, and ferroptsosis sensitivity
    May 17, 2023 Juntao Yu Moazed DNA replication-coupled parental histone transfer and epigenetic inheritance
    June 7, 2023 Kumar Aavula Van Vactor miRNA mediated regulation of activity induced synaptic plasticity
    June 14, 2023 Jennifer Waters, Tally Lambert, Federico Gasparoli NIC Online tools for learning and performing light microscopy

  • 2021-2022
    DATE SPEAKER LAB TALK TITLE
     Sep 15, 2021 Zhejian Ji Rapoport Lab Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
     Sep 22, 2021 Jiaxin Liang Puigserver Lab Endosome Trafficking Defines Mevalonate Pathway Sensitivity in Tumor Resistance
     Sep 29, 2021 Leila Revollo Whitman Lab Establishing functions for the secreted tyrosine kinase VLK
     Oct 20, 2021 Jiaming Li Gygi Lab Proteome-wide mapping of short-lived proteins in human cells
     Nov 17, 2021 Haopeng Xiao Chouchani Lab Architecture of the outbred brown fat proteome defines regulators of metabolic physiology
     Dec 15, 2021 Vincent Chu Shao Lab Selective destabilization of polypeptides synthesized from NMD-targeted transcripts
     Jan 5, 2022 Kumar Aavula Van Vactor Lab miRNA mediated regulation of activity induced synaptic plasticity
     Jan 12, 2022 Bryan Seguinot Finley Lab TBCEL-mediated degradation of tubulin during red blood cell differentiation
     Jan 19, 2022 Melanie Mittenbuhler Spiegelman Lab Isolation of interstitial fluids reveals novel secreted bioactive proteins from muscle and fat tissues
     Feb 9, 2022 Giuseppe Di Caprio Kirchhausen Lab Deep neural network training for automated identification of intracellular substructures in volumetric electron microscopy
     Feb 16, 2022 Gengjing Zhao Pellman Lab The Mitotic Actin Cytoskeleton and Endoplasmic Reticulum Morphology Control the Pattern of Nuclear Envelope Assembly
     Feb 23, 2022 Judy Shen Sander Lab Study of combination therapy in ovarian cancer using mass-spectrometry based proteomics
     Mar 9, 2022 Donghoon Lee Goldberg Lab

    Molecular mechanisms for activation of 26S proteasome and p97 by ZFAND5
     Mar 16, 2022 Shaoni Mukhopadhyay Lee Lab

    Regulation of the Epitranscriptome via eIF3d during the Integrated Stress Response (ISR)
     Mar 30, 2022 Henning Arlt  Farese/Walther Lab

    Mechanistic insight into lipid droplet biogenesis
     Apr 6, 2022 Melissa Hoyer Harper Lab

    Organelle quality control in neuronal cells
     Apr 13, 2022 Aaron Hosios Manning Lab mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species
     Apr 20, 2022  Xiangkun Han Brugge Lab NRF2, the master regulator of more than anti-oxidative stress
     Apr 27, 2022 Accalia Fu Danial Lab Glucose fuels choice metabolic paths for pancreatic b-cell survival in inflammation
     May 11, 2022 Haining Zhou Moazed Lab “Nascent RNA Degradation on Chromatin Contributes to Gene Repression”
     May 18, 2022 Farah Haque Subramanian Lab “Cytoskeletal regulation of a transcription factor by DNA mimicry”
     May 25, 2022 Chen Ran Liberles Lab "Optical deciphering of internal sensory codes in the brain"
     Jun 1, 2022 Peiqing Feng Rapoport Lab "The tale of three RINGS: a heterotrimeric ubiquitin ligase complex forms the peroxisomal retro-translocon"
     Jun 8, 2022 Tomer M. yaron Cantley Lab "The Kinase Library: A Global Atlas of the Human Protein Kinome"

  • 2020-2021
    DATE SPEAKER LAB TALK TITLE
    Sep 16, 2020 Pushpa Sharma Van Vactor Lab microRNA, miR-1000 mediated control of metabolism via a novel neuropeptide
    Sep 23, 2020 Phillip Dumesic Spiegelman Lab Translational regulation of PGC1α and oxidative metabolism
    Sep 30, 2020 Heng Zhao Yuan Lab Modulating TRADD to restore cellular homeostasis and inhibit apoptosis
    Oct 7, 2020 Xudong Wu Rapoport Lab Mechanism of ERAD-L mediated by the Hrd1 complex
    Oct 21, 2020 Dylan Mitchell Gygi Lab A Proteome-Wide Map of Drug Mechanism of Action
    Oct 28, 2020 Mike McKenna Shao Lab The P5A-ATPase is a transmembrane helix dislocase
    Nov 18, 2020 Sharon Hung Finley Lab Modulation of cholesterol metabolism by UBE3B
    Dec 9, 2020 Navdar Sever Rapoport Lab Mechanism of lamellar body formation by lung surfactant protein B
    Dec 16, 2020 Brad Wierbowski Salic Lab A Molecular Relay for Sending and Receiving Hedgehog Signals (Dissertation in 25 Min)
    Jan 13, 2021 Ilaria Elia Haigis Lab Modulating pyruvate fate improves metabolic fitness of CD8+ T cells in tumors
    Jan 20, 2021 Pedro Latorre-Muro Puigserver Lab A cold-inducible PERK/OGT axis controls TOM70-assisted protein import and cristae formation
    Jan 27, 2021 Ben Fram Sander Lab Generating Sequence-divergent Proteins Using an Evolution-based Model of Protein Function
    Feb 17, 2021 Dong Wook Choi Danial Lab Metabolic Fuel Preference and the Excitable Brain
    Mar 10, 2021 Kenneth Gray Brugge Lab The Protean Lives and Times of the Alveolar Progenitor
    Mar 17, 2021 Galen Collins Goldberg Lab The Shuttling Factor & Protease Ddi2 Regulates Protein Degradation and Antigen Presentation
    Mar 31, 2021 Anita Reddy Chouchani Lab Examining the Role of Succinate Signaling in Muscle Remodeling Following Exercise
    Apr 7, 2021 Mitchell Leibowitz Pellman Lab Chromothripsis as an on-target consequence of genome editing
    Apr 14, 2021 Francois Thelot Liao Lab Working harder, not smarter: wasteful ATP hydrolysis by the lipopolysaccharide floppase MsbA
    Apr 21, 2021 Jianhua Shi Flanagan Lab Tau is a novel substrate for Protein Tyrosine Phosphatase σ(PTPσ) -participating in PTPσ mediated neurodevelopment, neural injury and degeneration
    Apr 28, 2021 Anwesha Sanyal Kirchhausen Lab Inhibition of PIKfyve kinase prevents alpha-synuclein aggregation and averts neuronal cell death
    May 12, 2021 Marito Hayashi Liberles Lab Gut-brain communication mechanisms underlying feeding control
    May 19, 2021 Tiasha Shafiq Moazed Lab DNA-Sequence Dependent Epigenetic Inheritance in Mammalian Cells
    May 26, 2021 Hankum Park Harper Lab Quantitative proteomics for endo-lysosomal amyloid processing in Alzheimer's disease
    Jun 2, 2021 Aditi Jatkar Farese/Walther Lab Mechanism underlying the regulation of SREBP-1 activation by glycerolipids

  • 2019-2020
    DATE SPEAKER LAB TALK TITLE
    Sep 11, 2019 Eduardo Balsa Martinez Puigserver Lab Defective NADPH Production in Mitochondrial Disease Complex I Causes Inflammation and Cell Death
    Sep 18, 2019 Marie Bao Departments of Cell Biology and BCMP Tips on Getting Published: Insights into the Editorial Process
    Oct 9, 2019 Marcelo Cicconet IDAC Mobile, cloud, assistants, machine learning: analyzing images like it's 2019
    Oct 23, 2019 Jiuchun Zhang Initiative CRISPR Services at the Cell Biology Initiative
    Oct 30, 2019 Mohan Chitraju Farese/Walther Lab Life without fat: insights into energy balance from a novel murine model
    Nov 13, 2019 Jeeyun Chung Farese/Walther Lab the protein machinery of lipid droplet formation
    Nov 20, 2019 Maria Del Carmen Fernandez-Aguera Rodriguez Danial Lab Metabolic Fuel Preference and the Excitable Brain
    Dec 4, 2019 Reza Behrouzi Moazed Lab what we talk about when we talk about heterochromatin
    Dec 18, 2019 Erdem Sendinc Shi Lab Regulation of gene expression through RNA modifications
    Jan 15, 2020 Yaara Oren Brugge Lab Using Watermelons to uncover metabolic adaptations of cancer persister cells
    Jan 22, 2020 Yizhi Sun Spiegelman Lab Futile Creatine Cycle: Novel Pathway of Thermogenesis
    Jan 29, 2020 Masanori Naito Yuan Lab Apoptosis and necroptosis in a disease model
    Feb 5, 2020 Alban Ordureau Harper Lab Molecular Roadmap to PINK1/Parkin Mitophagy Signaling
    Feb 19, 2020 Valentina Rossio King Lab Unmasking functional redundancy of deubiquitylases reveals a prominent role of USP7 in rescuing proteins from degradation
    Feb 26, 2020 David Nusinow Gygi Lab Quantitative Proteomics of the Cancer Cell Line Encyclopedia
    Mar 4, 2020 Xuewu Sui Liao Lab Structure and catalytic mechanism of a human triacylglycerol synthesis enzyme
    Apr 8, 2020 GaYoung Lee Liberles Lab Not all those who wander are lost: Mechanisms underlying organ-specific targeting by the vagus nerve
    Apr 15, 2020 Alexandra Franz Sander Lab Building signaling network models using mass spectrometry-based proteomics
    Apr 22, 2020 Jefte Drijvers Haigis Lab Metabolic screening identifies ferroptosis as a vulnerability of CD8+ T cells
    Apr 29, 2020 Neil Umbreit Pellman Lab Mechanisms generating cancer genome complexity from a single cell division error
    May 13, 2020 Haopeng Xiao Chouchani Lab A quantitative tissue-specific landscape of protein redox regulation during aging
    May 20, 2020 Jordan Verplank Goldberg Lab Raising cGMP to activate the Ubiquitin Proteasome System and prevent proteotoxic diseases

  • 2018-2019
    DATE SPEAKER LAB TALK TITLE
    Sep 12, 2018 Jim Gould Harvard Medical School Making the Most of Your Training Experience at HMS
    Sep 19, 2018 Zhe Sha Goldberg Lab Inhibition of ubiquitination causes sumoylation of nuclear proteins
    Sep 26, 2018 Valentina Rossio King Lab Proteomic analysis of deubiquitinating enzyme targets and specificity in Xenopus extract
    Oct 17, 2018 Xing Zeng Spiegelman Lab Innervation of Thermogenic Adipose Tissue through a Clstn3β/S100b Axis
    Oct 24, 2018 Ayaz Najafov Yuan Lab Escape from necroptosis in cancer
    Oct 31, 2018 Xudong Wu Rapoport Lab Structural basis of ERAD mediated by the Hrd1 ubiquitin ligase complex
    Nov 14, 2018 Chi Luo Puigserver Lab Multifaceted Roles of PGC1a in Melanoma Pathogenesis
    Nov 28, 2018 Sharan Swarup Harper Lab The retromer complex regulates trafficking of lysosomal proteins
    Dec 12, 2018 Talley Lambert Nikon Imaging Center FPbase.org: a community-editable fluorescent protein database and microscopy resource
    Dec 19, 2018 Wanqiang Sheng Shi Lab Investigating the role of LSD1 in tumor immunity and immunotherapy
    Jan 9, 2019 Jon Van Vranken Gygi Lab The role of mitochondrial fatty acid synthesis in supporting cellular respiration
    Jan 30, 2019 Xuewu Sui Farese/Walther Lab Cryo-electron microscopy structure of the lipid droplet-formation protein seipin
    Feb 6, 2019 Yanyan Li Liao Lab Structural Snapshots of Lipopolysaccharide Extraction from Bacterial Inner Membrane
    Feb 13, 2019 Nao Horio Liberles Lab The olfactory circuit of aversive behavior in zebrafish
    Feb 20, 2019 Dong Wook Choi Danial Lab Regulation of de novo lipogenesis through a glucose sensitive transcriptional complex
    Feb 27, 2019 Gergana Shipkovenska Moazed Lab Epigenetic inheritance in the fission yeast
    Mar 6, 2019 Ilja Kusters Kirchhausen Lab Reconstitution of clathrin coated pit budding probed by single molecule imaging
    Mar 20, 2019 Suha Abu Amara Brugge Lab Transient commensalism drives metastasis in a model of ovarian clear cell carcinoma
    Mar 27, 2019 Mike Stiffler Sander Lab Protein Structure from Laboratory Evolution
    Apr 3, 2019 Alex Whiteley Finley Lab Using global proteomics of Ubqln2-mediated mouse models of ALS to reveal client proteins and potential pathways of disease development
    Apr 24, 2019 Elma Zaganjor Haigis Lab The role of mitochondria in adipogenesis
    May 1, 2019 I-Ju Lee Pellman Lab Nuclear Envelope Sealing: The ESCRT Machinery and More
    May 15, 2019 Matthew Yip Shao Lab tRNA recycling and quality control from stalled ribosomes
    May 22, 2019 Jianhua Shi Flanagan Lab HSPG inhibits scar formation and promotes axon regeneration and functional recovery after spinal cord injury
    Jun 5, 2019 Evanna Mills Chouchani Lab Succinate accumulation controls activation of adipose tissue thermogenesis
    Jun 12, 2019 Donghoon Lee Goldberg Lab ZFAND5 is a novel activator of proteasome and protein degradation
    Jun 19, 2019 Brandon Woods Van Vactor Lab miRNA Control of Synaptic Morphogenesis
    Jun 26, 2019 Ed Twomey Rapoport Lab Cryo-EM reveals mechanism of substrate processing by the Cdc48 ATPase complex

  • 2017-2018
    DATE SPEAKER LAB TALK TITLE
    Sep 13, 2017 Amir Karger Research Computing HMS Research Computing: Helping CellBio Researchers Do Good (Fast!) Science on Computers
    Sep 20, 2017 Niklas Mejhert Farese/Walther Lab Genetic determinants of lipid storage in macrophages
    Sep 27, 2017 Sara Prescott Liberles Lab Building a 'Vagal Atlas': Clues to Internal Sensory Systems
    Oct 4, 2017 Xinmin Li Flanagan Lab Axon Guidance at Intermediate Target Through Local Translation
    Oct 18, 2017 Heeseon An Harper Lab Systematic Analysis of Ribophagy in Human Cells
    Oct 25, 2017 Nobu Takahashi Brugge Lab Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative Stress Tolerance
    Nov 8, 2017 Hugo Santos Van Vactor Lab Untangled but still tied in knots: from SMA disease model transcriptomes to a SMN-specific gene regulatory network
    Nov 15, 2017 Bradley Wierbowski Salic Lab How many factors does it take to move a Hedgehog: defining a necessary pathway upstream of ligand reception
    Nov 29, 2017 Lin Deng Pellman Lab Premature mitotic entry induces genome instability by unloading DNA replicative helicase
    Dec 6, 2017 Sejal Vyas Haigis Lab SIRT4 regulation of intestinal homeostasis in the DNA damage response
    Dec 13, 2017 Gokul Upadhyayula Kirchhausen Lab Observing the Cell in Its Native State: Imaging Subcellular Dynamics in Multicellular Organisms
    Jan 3, 2018 Huibing Wang Yuan Lab PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP
    Jan 10, 2018 Nicholas Bodnar Rapoport Lab Structure of the Cdc48 ATPase with its cofactors Ufd1 and Npl4
    Jan 24, 2018 Seth Johnson Van Vactor Lab Determining the role of TACC in the development of the synapse in Drosophila
    Jan 31, 2018 Hyeonwoo "Chad" Kim Spiegelman Lab Irisin Mediates Beneficial Exercise-induced Effects via Integrins
    Feb 7, 2018 Eduardo Balsa Puigserver Lab ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes Through PERK/eIF2α Axis
    Feb 14, 2018 Alban Ordureau Harper Lab Spatial control of ubiquitin signals underlying mitophagy
    Feb 21, 2018 Calie Fu Danial Lab Glucose-dependent partitioning of arginine to urea cycle protects beta cells from inflammation
    Feb 28, 2018 Kevin Jiang HMS Media Office Science, News, and You
    Mar 14, 2018 Michael Weber Nikon Imaging Center New possibilities for imaging your sample - microscope upgrades in the NIC
    Mar 21, 2018 Jamie Anastas Shi Lab Targeting chromatin to induce differentiation in pediatric brain cancer
    Mar 28, 2018 Mark Jedrychowski Gygi Lab Characterizing redox control of thermogenesis
    Apr 4, 2018 Maja Edenius Whitman Lab Characterization of a Novel Mammalian Nutritional Stress Response Pathway
    Apr 11, 2018 Ben Orlando Liao Lab Structure of the Mitochondrial Calcium Uniporter from Cryo-EM and X-ray Crystallography
    May 2, 2018 Mark Currie Moazed Lab Clr4/Suv39h autoregulation prevents illegitimate heterochromatin formation
    May 9, 2018 Josh Wilson-Grady Finley Lab The Biochemical Program of Extreme Terminal Differentiation
    May 16, 2018 Alexandra Franz Sander Lab Systems Biology of Combination Therapy in Ovarian Cancer
    May 24, 2018 Alison Ringel Haigis Lab Immunomodulatory mechanisms in the tumor microenvironment
    Jun 6, 2018 Jordan VerPlank Goldberg Lab Raising cGMP enhances protein degradation and proteasome function
    Jun 13, 2018 Alex Keszei Shao Lab Progress towards a structural view of protein triage

  • 2016-2017
    DATE SPEAKER LAB TALK TITLE
    Sep 21, 2016 Yannis Zervantonakis Brugge Lab Systems analysis of signaling pathway adaption after PI3K-pathway inhibition to design effective ovarian cancer combination therapies
    Oct 5, 2016 Kai Hu Olsen Lab VEGF-dependent Mechanisms in Bone Repair
    Oct 19, 2016 Selwin Wu Pellman Lab Mechanisms linking centrosome amplification to the senescence associated secretory phenotype in cancer
    Oct 26, 2016 Wei Mi Liao Lab cryoEM structures and mechanism of flippase in membrane
    Nov 30, 2016 Yulu "Cherry" Liu Salic Lab Hedgehog Signaling in Ciliopathies
    Dec 7, 2016 Brian Cunniff Kirchhausen Lab Mitochondrial positioning by Miro1 supports cell migration and clathrin mediated endocytosis
    Dec 14, 2016 Yasushi Ito Yuan Lab RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
    Jan 4, 2017 Robert Powers Rapoport Lab Reconstitution of the tubular endoplasmic reticulum network with purified component
    Jan 11, 2017 Pushpa Sharma, PhD Van Vactor Lab Role of microRNA, miR-980 in immune system of Drosophila melanogaster
    Jan 25, 2017 Jessica Spinelli Haigis Lab Metabolic Recycling of Ammonia Facilitates Breast Cancer Growth and Proliferation
    Feb 1, 2017 Danial Egan Spiegelman Lab Decoding PGC1a1 control of Energy Metabolism
    Feb 8, 2017 Kfir Sharabi Puigserver Lab Small Molecule Screen Identifies Selective PGC-1α Gluconeogenic Inhibitors that Ameliorate Diabetic Symptoms
    Feb 22, 2017 Jin-Mi Heo Harper Lab Spatio-temporal mapping of the PINK1-PARKIN mitophagy pathway
    Mar 1, 2017 Sofia Ribeiro Danial Lab Metabolic control of neuronal activity by fuel substrate switching: A role for BAD
    Mar 15, 2017 Talley Lambert Nikon Imaging Center Lattice Light Sheet Microscopy in the Cell Biology Microscopy Facility
    Mar 22, 2017 Violetta Karwacki-Neisius Shi Lab Elucidating the role of the histone demethylase KDM5C in intellectual disability
    Mar 29, 2017 Julian Mintseris Gygi Lab High Density Chemical Cross-linking for Modeling Protein Interactions
    Apr 5, 2017 Yeonjin Kim Whitman Lab The Amino Acid Starvation Response Inhibits Inflammatory Diseases by a Novel Mechanism
    Apr 26, 2017 Min Luo Liao Lab Invader capture in CRISPR - Viewing is believing!
    May 10, 2017 Xiaoyi Wang Moazed Lab DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation
    May 17, 2017 Alexandra Greer Finley Lab Ubiquilin1 promotes stimulus-dependent proliferation by eliminating mislocalized mitochondrial proteins
    May 24, 2017 Galen Collins Goldberg Lab Another Mechanism Regulating the 26S Proteasome: Ubiquitin Life (UbL) Domains Activate Multiple Steps in Conjugate Degradation
    May 31, 2017 Benjamin Schubert Sander Lab Population-specific design of de-immunized protein biotherapeutics
    Jun 7, 2017 Haejin Yoon Haigis Lab AMPK opposes PHD3 to promote fat oxidation through ACC2
    Jun 14, 2017 Binkai Chi Reed Lab Analysis of ALS-causative RNA binding proteins reveals that common factors are shared by motor neuron diseases

  • 2015-2016
    DATE SPEAKER LAB TALK TITLE
    Oct 7, 2015 Kostadin Petrov Salic Lab The Mechanism of Patched Inhibition by Sonic Hedgehog
    Oct 21, 2015 Kangmin He Kirchhausen Lab Direct probing of dynamic phosphoinositide switches during clathrin-mediated endocytosis
    Oct 28, 2015 Neil Umbreit Pellman Lab A new model for chromosome bridge resolution based on nuclear envelope fragility and DNA damage
    Nov 18, 2015 Su Chiang, Grant Zimmerman and Leandro Vetcher Office of Technology Devlopment The Blavatnik Biomedical Accelerator: Supporting Applied Life Sciences at Harvard
    Dec 2, 2015 Isaac Harris Brugge Lab Looks can be deceiving: the roles of antioxidants in cancer
    Dec 16, 2015 Julie Chen Rapoport Lab Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion
    Jan 6, 2016 Karina Gonzalez Haigis Lab Identifying metabolic vulnerabilities in tumors with low SIRT3
    Jan 13, 2016 Huajin Wang Farese/Walther Lab How Do Lipid Droplets Form From the Endoplasmic Reticulum? - Lessons From Studying The Lipodystrophy Protein Seipin
    Jan 27, 2016 Ed Chouchani Spiegelman Lab Mitochondrial redox control of thermogenic adipose function
    Feb 3, 2016 Israel Pichardo-Casas Van Vactor Lab Muscle maintenance and ALS: a common microRNA theme?
    Feb 10, 2016 Joeva Barrow Puigserver Lab Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations
    Feb 24, 2016 Talley Lambert Nikon Imaging Center Light sheet microscopy and other new resources in the Cell Biology Microscopy Facility
    Mar 2, 2016 Long Li Rapoport Lab Crystal structure of a substrate-engaged SecY protein-translocation channel
    Mar 9, 2016 Robert Liefke Shi Lab TBAGenome-wide modulation of transcription by the PRC2-associated factor C17orf96
    Mar 23, 2016 Liz Lane Danial Lab Glucose sensing and de novo lipogenesis
    Mar 30, 2016 Laura Pontano-Vaites Harper Lab Mechanisms of selective autophagy and autophagosome maturation
    Apr 6, 2016 Su Wu Naar Lab SREBP1-driven Lipogenesis Pathway in Melanoma
    Apr 13, 2016 Qian Li Liberles Lab Non-canonical amine recognition evolved in a large clade of olfactory receptors
    Apr 20, 2016 Leila Revollo Whitman Lab The role of VLK in the dynamics of extracellular matrix
    May 4, 2016 Jiefei Geng Yuan Lab TAK1-mediated RIPK1 phosphorylation negatively regulates RIPK1-dependent apoptosis
    May 11, 2016 Gloria Jih Moazed Lab RNAi@chromatin.pombe (Pizza Emoji) (Pizza Emoji) #H3K9methylation #genesilencing
    May 18, 2016 Stefanie De Poot Finley Lab Unraveling the function of the proteasomal deubiquitinating enzyme UCH37
    May 25, 2016 Chueh-Ling Kuo Goldberg Lab Ubiquitin conjugates promote the association of Usp14 and Ube3c with proteasomes

  • 2014-2015
    DATE SPEAKER LAB TALK TITLE
    Sep 24, 2014 Pengxiang Huang Salic Lab Activation of Hedgehog Signaling by Sterol-Triggered Conformational Switch in Smoothened
    Oct 1, 2014 Frances Evesson Kirchhausen Lab Dysferlin to the rescue! Membrane repair in skeletal muscle cells
    Oct 8, 2014 Hugo Arellano-Santoyo Pellman Lab Towards an understanding of the molecular mechanism of the unique biomechanical properties of the yeast kinesin-8 Kip3
    Oct 22, 2014 Shanye Yin Reed Lab Functional coupling of RNAP II transcription to pri-miRNA processing
    Oct 29, 2014 Noga Ron-Harel Haigis Lab A Synchronized Program of Mitochondrial Remodeling and Fuel Metabolism Supports Naïve T cell Activation
    Nov 5, 2014 Lisa Gallegos Brugge Lab  
    Nov 12, 2014 Fabian Romano-Chernac Rapoport Lab
    Nov 19, 2014 Nora Kory Farese & Walther Lab
    Dec 3, 2014 Romain Christiano Farese & Walther Lab
    Jan 21, 2015 Kfir Sharabi Puigserver Lab
    Feb 4, 2015 Lawrence Kazak Spiegelman Lab
    Feb 18, 2015 Zhe Sha Goldberg Lab
    Feb 19, 2015 Accalia Fu Danial Lab  
    Mar 4, 2015 Wei Huang Olsen Lab  
    Mar 11, 2015 Benoit Laurent Shi Lab  
    Mar 18, 2015 Xinmin Li Flanagan Lab
    Apr 8, 2015 Christian Munch Harper Lab  
    Apr 15, 2015 Hongguang Xia Yuan Lab  
    Apr 29, 2015 Ryan Baldridge Rapoport Lab Exploring ERAD retro-translocation using a reconstituted system
    May 6, 2015 Talley Lambert Nikon Imaging Center First impressions and optimization of 3D-structured illumination microscopy on the OMX Blaze
    May 13, 2015 Rui Chang Liberles Lab Vagal sensory neuron subtypes that differentially control breathing
    May 27, 2015 Miguel Prado Finley Lab Remodeling of the proteome by USP14
    Jun 3, 2015 Alexandre Wagschal Naar Lab Genome-wide identification of microRNAs regulating cholesterol/lipid homeostasis
    Jun 10, 2015 Kaushik Ragunathan Moazed Lab How cells create and maintain memories of gene expression

  • 2013-2014
    DATE SPEAKER LAB TALK TITLE
    Sep 25, 2013 Marcin Iwanicki Brugge Lab Targeting Mutant p53 and Cell-Cell Adhesion in Ovarian Cancer
    Oct 2, 2013 Xiaoxiao Gu Blenis Lab Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis (LAM) pathogenesis
    Oct 9, 2013 W. Bret Redwine Reck-Peterson Lab The mystery of processivity: towards an understanding of the basis of motor properties in vivo
    Oct 30, 2013 Jennifer Long Van Vactor Lab The role of microtubule dynamics during nervous system development
    Nov 6, 2013 Ruby Yu Moazed Lab Identification of locus features that permit targeting by RNAi-mediated heterochromatin in fission yeast
    Nov 13, 2013 Kwonmoo Lee Danuser Lab Mechanosensitivity in the Cooperative Dynamics of Actin Nucleators During Epithelial Cell Protrusion
    Dec 4, 2013 Helin Norberg Yuan Lab Identification of a novel Degradation Pathway for Mutant p53
    Dec 11, 2013 Yong Yu Reed Lab U1 snRNP and FUS in coupling transcription to pre-mRNA splicing
    Jan 15, 2014 Benedikt Bauer Rapoport Lab Elucidating the molecular mechanism of protein translocation by the SecA-ATPase
    Jan 29, 2014 Nikolay Kukushkin Goldberg Lab Proteasome autoubiquitination regulates its function
    Feb 5, 2014 Daniel Nedelcu Salic Lab Regulation of Smoothened in the Hedgehog Pathway
    Feb 12, 2014 Seung Min Jeong Haigis Lab Regulation of metabolic response to DNA damage by SIRT4
    Feb 26, 2014 Michael Weekes Gygi Lab Quantitative Temporal Viromics: a new approach to investigate host-pathogen interaction
    Mar 5, 2014 Yoonjin Lee Puigserver Lab Cyclin D1-CDK4 controls glucose metabolism independently of cell cycle progression
    Mar 12, 2014 Maude Baldwin Liberles Lab Evolution of sweet taste perception in a nectar-feeding bird
    Mar 26, 2014 Po-Lin Chiu Walz Lab Structural studies of lipid-protein interactions by using two-dimensional crystals of aquaporin-0
    Apr 2, 2014 Melissa Hancock Flanagan Lab Role of miRNA in axon development
    Apr 9, 2014 Illana Stanley Danial Lab Metabolic Heterogeneity in Molecular Subsets of Diffuse Large B-Cell Lymphoma
    Apr 30, 2014 Mijung Kwon Pellman Lab How cancer cells divide with too many centrosomes: the Achilles’ heel of cancer cells
    May 1, 2014 Alex Stein Rapoport Lab
    May 7, 2014 Anne White Harper Lab Quantitative analysis of the Hippo pathway in low and high-density cells
    May 14, 2014 Andres Blanco Shi Lab RNAi screens for epigenetic regulators of differentiation in Acute Myeloid Leukemia

  • 2012-2013
    DATE SPEAKER LAB TALK TITLE
    Jan 9, 2013 Alexis Lomakin Danuser Lab Myosin-II serves as global inhibitor of self-organizing polarity in immotile cells
    Feb 6, 2013 Anthony Nguyen Finley Lab Ubiquitination in Erythropoiesis and the Pathophysiology of Anemias
    Feb 13, 2013 Gaelle Laurent Haigis Lab SIRT4 controls the balance between lipid synthesis and catabolism by repressing malonyl-CoA Decarboxylase
    Feb 26, 2013 Michael Weekes Gygi Lab  
    Mar 6, 2013 Rebecca Mathew Moazed Lab Storing memories: the role of miR-153 in long-term memory formation
    Mar 13, 2013 Grant Zimmermann Brugge Lab  
    Apr 10, 2013 Neil Ganem Pellman Lab Tetraploidy, Aneuploidy,and Cancer
    Jun 5, 2013 Dongyan Tan Walz Lab Structural and functional studies on the tethering complex TRAPPIII
    Jun 12, 2013 Elizabeth McNeil Van Vactor Lab Tools to define microRNA regulatory complexity in Drosophila