Previous Fawcett Lectures
2023
Susan Gasser, Ph.D., Director, ISREC Foundation
I. "Nuclear subcompartments: genetic evidence for function from yeast to man"
II. "How heterochromatin mediates genome stability and tissue integrity in metazoans”
2022
Dirk Görlich, Ph.D., Max Planck Institute for Multidisciplinary Sciences, Göttingen
I. "Wnt, gut stem cells and cancer"
II. "Organoids as avatars of human disease”
2019
Hans Clevers, Ph.D., Hubrecht Institute for Developmental Biology and Stem Cell Research
I. "Wnt, gut stem cells and cancer""
II. "Organoids as avatars of human disease”
2018
Edith Heard, Ph.D., Institut Curie & College de France
I. "The evolutionary and epigenetic dynamics of X-chromosome inactivation"
II. "Building heterochromatin: chromosome structure meets function on the X chromosome”
2017
Pietro De Camilli, M.D., Yale University School of Medicine
I. "Contact sites between organelles in the control of lipid transport and membrane identity"
2016
Craig B. Thompson, M.D., Memorial Sloan Kettering Cancer Center
I. "Connecting cellular metabolism to growth and differentiation"
II. "Translating metabolic insights into therapies”
2015
Thomas D. Pollard, M.D., Yale University
I. “The Molecular Mechanism of Cellular Motility”
II. "The Molecular Mechanism of Cytokinesis”
2014
Titia de Lange, Ph.D., Rockefeller University
I. “Breaking bad: How telomeres hide from the DNA damage response”
II. “Breaking away: Using telomeres to understand the DNA damage response”
2013
James E. Rothman, Ph.D., Yale School of Medicine
I. “The mechanism of synchronous release of neurotransmitters at synapses”
II. “Protein dynamics in the golgi apparatus”
2011
Franz-Ulrich Hartl, M.D., Max Planck Institute of Biochemistry
I. “Chaperone mechanisms in protein folding and assembly”
II. “Proteotoxicity of ß-Aggregation: Mechanisms and defense by molecular chaperones”
2009
Martin Chalfie, Ph.D., Columbia University
I. “Adventures in Non-translational Research: 1. GFP”
II. “Adventures in Non-translational Research: 2. Mechanosensation”
2008
Scott D. Emr, Ph.D., Cornell University
I. “Sorting out receptor downregulation: getting to know your ESCRTs”
II. “Phosphoinositide lipid signaling in the regulation of membrane transport and organelle identity”
2007
Walter Neupert, M.D., Ph.D., University of Munich
I. “Biogenesis of mitochondria: The protein import machineries”
II. “Mitochondria and their bacterial ancestors: Evolutionary conservation of the assembly of mitochondrial membranes”
2006
Dan Klionsky, Ph.D., University of Michigan
How to live a longer, healthier, dementia-free life through autophagy
Beth Levine, M.D., UT Southwestern Medical School
“Autophagy, metazoan biology, and human disease”
2005
Andrew Fire, Ph.D., Stanford University
“Homology-directed genetic surveillance mechanisms”
Craig Mello, Ph.D., University of Massachusetts
“RNAi & developmental mechanisms in C. elegans”
2004
Eric Wieschaus, Ph.D., Princeton University
“From gradients to local cell shape changes in drosophila embryos”
2003
C. David Allis, Ph.D., Rockefeller University
“Beyond the double helix: Writing & reading the histone code”
2002
Susan Lindquist, Ph.D., Whitehead Institute/MIT
“Surprises from protein folding”
2000
Elizabeth Blackburn, Ph.D., UC San Francisco
“Telomere capping and cell proliferation”
1998
Randy Scheckman, Ph.D., UC Berkeley
“Vesicular packaging of secretory and membrane proteins”
1996
Gunter Blobel, M.D., Ph.D., University of Wisconsin
“How proteins most likely move into and out of the nucleus”
1993
Mark W. Kirschner, Ph.D., UC San Francisco
“Cyclins, centrioles, and cell cycles”
1992
Russell Ross, Ph.D., University of Washington
“Cellular responses to injury and atherosclerosis: The roles of growth factors”
1990
Joseph L. Goldstein, M.D., University of Texas
“How cells control cholesterol”
1988
George E. Palade, M.D., Yale University
“Membrane traffic in eukaryotic cells”