Lipid droplets (LDs) are organelles bound by a single layer of phospholipids that store neutral lipids for energy metabolism and cell membrane homeostasis. Perturbations to LD biology are associated with atherosclerosis, cancer, neurodegeneration, and other diseases, but attempts to study LDs have been fragmented. The lab of Robert Farese & Tobias Walther, along with Broad colleagues have created the Lipid Droplet Knowledge Portal, a platform that integrates transcriptomics, proteomics, and genomics data from fly, human, and mouse cells. LD-portal also connects to other databases such as the Common Metabolic Diseases Knowledge Portal. In Developmental Cell, the team describes several examples using LD-Portal to study LD biology.